A prospective study on the wound healing and quality of life outcomes of patients with venous leg ulcers in Singapore-Interim analysis at 6 month follow up.

Autor: Chan KS; Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore., Lo ZJ; Department of Surgery, Woodlands Health, Singapore, Singapore., Wang Z; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Bishnoi P; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ng YZ; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chew S; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chong TT; Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore., Carmody D; Department of Endocrinology, Singapore General Hospital, Singapore, Singapore., Ang SY; Nursing Division, Singapore General Hospital, Singapore, Singapore., Yong E; Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore., Chan YM; Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore., Ho J; Department of Cardiac, Thoracic & Vascular Surgery, National University Hospital, Singapore, Singapore., Graves N; Health Services & Systems Research, Duke-NUS Medical School, Singapore, Singapore., Harding K; Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Jazyk: angličtina
Zdroj: International wound journal [Int Wound J] 2023 Sep; Vol. 20 (7), pp. 2608-2617. Date of Electronic Publication: 2023 Mar 13.
DOI: 10.1111/iwj.14132
Abstrakt: Venous leg ulceration results in significant morbidity. However, the majority of studies conducted are on Western populations. This study aims to evaluate the wound healing and quality of life for patients with venous leg ulcers (VLUs) in a Southeast Asian population. This is a multi-centre prospective cohort study from Nov 2019 to Nov 2021. All patients were started on 2- or 4-layer compression bandage and were reviewed weekly or fortnightly. Our outcomes were wound healing, factors predictive of wound healing and the EuroQol 5-dimensional 5-level (EQ-5D-5L) health states. Within our cohort, there were 255 patients with VLU. Mean age was 65.2 ± 11.6 years. Incidence of diabetes mellitus was 42.0%. Median duration of ulcer at baseline was 0.30 years (interquartile range 0.136-0.834). Overall, the median time to wound healing was 4.5 months (95% confidence interval [CI]: 3.77-5.43). The incidence of complete wound healing at 3- and 6-month was 47.0% and 60.9%, respectively. The duration of the wound at baseline was independently associated with worse wound healing (Hazard ratio 0.94, 95% CI: 0.89-0.99, P = .014). Patients with healed VLU had a significantly higher incidence of perfect EQ-5D-5L health states at 6 months (57.8% vs 13.8%, P < .001). We intend to present longer term results in subsequent publications.
(© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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