Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study.

Autor: Shannon OM; Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Ranson JM; College of Medicine and Health, University of Exeter, Exeter, UK., Gregory S; Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Macpherson H; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia., Milte C; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia., Lentjes M; School of Medical Sciences, Örebro University, Örebro, Sweden., Mulligan A; Nutrition Measurement Platform, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., McEvoy C; Centre for Public Health, The Institute for Global Food Security, Queen's University Belfast, Belfast, UK., Griffiths A; School of Health, Leeds Beckett University, Leeds, UK., Matu J; School of Health, Leeds Beckett University, Leeds, UK., Hill TR; Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Adamson A; Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Siervo M; School of Life Sciences, Queen's Medical Centre, The University of Nottingham Medical School, Nottingham, UK., Minihane AM; Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.; Norwich Institute of Health Ageing (NIHA), Norwich, UK., Muniz-Tererra G; Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA., Ritchie C; Edinburgh Dementia Prevention, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Mathers JC; Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. John.Mathers@Newcastle.ac.uk., Llewellyn DJ; College of Medicine and Health, University of Exeter, Exeter, UK.; Alan Turing Institute, London, UK., Stevenson E; Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Jazyk: angličtina
Zdroj: BMC medicine [BMC Med] 2023 Mar 14; Vol. 21 (1), pp. 81. Date of Electronic Publication: 2023 Mar 14.
DOI: 10.1186/s12916-023-02772-3
Abstrakt: Background: The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) has been proposed to reduce dementia risk. However, current evidence is inconclusive and is typically derived from small cohorts with limited dementia cases. Additionally, few studies have explored the interaction between diet and genetic risk of dementia.
Methods: We used Cox proportional hazard regression models to explore the associations between MedDiet adherence, defined using two different scores (Mediterranean Diet Adherence Screener [MEDAS] continuous and Mediterranean diet Pyramid [PYRAMID] scores), and incident all-cause dementia risk in 60,298 participants from UK Biobank, followed for an average 9.1 years. The interaction between diet and polygenic risk for dementia was also tested.
Results: Higher MedDiet adherence was associated with lower dementia risk (MEDAS continuous: HR = 0.77, 95% CI = 0.65-0.91; PYRAMID: HR = 0.86, 95% CI = 0.73-1.02 for highest versus lowest tertiles). There was no significant interaction between MedDiet adherence defined by the MEDAS continuous and PYRAMID scores and polygenic risk for dementia.
Conclusions: Higher adherence to a MedDiet was associated with lower dementia risk, independent of genetic risk, underlining the importance of diet in dementia prevention interventions.
(© 2023. The Author(s).)
Databáze: MEDLINE
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