Cu-doped TiO 2 nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies.

Autor: Hesemans E; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Saffarzadeh N; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Maksoudian C; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Izci M; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Chu T; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Rios Luci C; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium., Wang Y; Leibniz Institute for Materials Engineering IWT, Badgasteiner Straße 3, 28359, Bremen, Germany.; Faculty of Production Engineering, University of Bremen, Badgasteiner Straße 1, 28359, Bremen, Germany., Naatz H; Leibniz Institute for Materials Engineering IWT, Badgasteiner Straße 3, 28359, Bremen, Germany.; Faculty of Production Engineering, University of Bremen, Badgasteiner Straße 1, 28359, Bremen, Germany., Thieme S; UniversitatsKlinikum, Dresden, Germany., Richter C; UniversitatsKlinikum, Dresden, Germany., Manshian BB; Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Leuven Cancer Institute, KU Leuven, Leuven, Belgium., Pokhrel S; Leibniz Institute for Materials Engineering IWT, Badgasteiner Straße 3, 28359, Bremen, Germany.; Faculty of Production Engineering, University of Bremen, Badgasteiner Straße 1, 28359, Bremen, Germany., Mädler L; Leibniz Institute for Materials Engineering IWT, Badgasteiner Straße 3, 28359, Bremen, Germany.; Faculty of Production Engineering, University of Bremen, Badgasteiner Straße 1, 28359, Bremen, Germany., Soenen SJ; NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. s.soenen@kuleuven.be.; Leuven Cancer Institute, KU Leuven, Leuven, Belgium. s.soenen@kuleuven.be.; KU Leuven Institute of Physics-Based Modeling for In Silico Health, KU Leuven, Leuven, Belgium. s.soenen@kuleuven.be.
Jazyk: angličtina
Zdroj: Journal of nanobiotechnology [J Nanobiotechnology] 2023 Mar 13; Vol. 21 (1), pp. 87. Date of Electronic Publication: 2023 Mar 13.
DOI: 10.1186/s12951-023-01844-z
Abstrakt: Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. We generated a series of copper-doped TiO 2 nanoparticles in order to tune the kinetics and full extent of Cu 2+ ion release from the remnant TiO 2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO 2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health.
(© 2023. The Author(s).)
Databáze: MEDLINE
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