Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality.

Autor: Jusue-Torres I; Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA., Tiv R; Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Ricarte-Filho JC; Cancer Center, University of Illinois at Chicago, Chicago, IL, USA., Mallisetty A; Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Contreras-Vargas L; Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Godoy-Calderon MJ; Cancer Center, University of Illinois at Chicago, Chicago, IL, USA., Khaddour K; Division of Hematology Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Kennedy K; Division of Hematology Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Valyi-Nagy K; Department of Pathology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., David O; Department of Pathology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Menchaca M; Department of Radiology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Kottorou A; Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece., Koutras A; Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece., Dimitrakopoulos F; Molecular Oncology Laboratory, Division of Oncology, Medical School, University of Patras, Patras, Greece., Abdelhady KM; Cancer Center, University of Illinois at Chicago, Chicago, IL, USA., Massad M; Division of Cardiothoracic Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Rubinstein I; Medical and Research Services, Jesse Brown VA Medical Center, Chicago, IL, USA.; Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Feldman L; Division of Hematology Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.; Medical and Research Services, Jesse Brown VA Medical Center, Chicago, IL, USA., Stewart J; Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.; Section of Surgical Oncology, Department of Surgery, Louisiana State University, New Orleans, LA, USA., Shimamura T; Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.; Division of Cardiothoracic Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL, USA., Danilova L; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia., Hulbert A; Cancer Center, University of Illinois at Chicago, Chicago, IL, USA. ahulbert@uic.edu.; Medical and Research Services, Jesse Brown VA Medical Center, Chicago, IL, USA. ahulbert@uic.edu.; Department of Surgery, University of Illinois College of Medicine, 909 South Wolcott Ave, COMRB Suite 5140, Chicago, IL, 60612, USA. ahulbert@uic.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Mar 13; Vol. 13 (1), pp. 4107. Date of Electronic Publication: 2023 Mar 13.
DOI: 10.1038/s41598-023-30765-y
Abstrakt: This study aims to perform a comprehensive genomic analysis to assess the influence of overexpression of MYO1E in non-small cell lung carcinoma (NSCLC) and whether there are differences in survival and mortality risk in NSCLC patients depending on both DNA methylation and RNA expression of MYO1E. The DNA methylation probe cg13887966 was inversely correlated with MYO1E RNA expression in both LUAD and LUSC subpopulations showing that lower MYO1E RNA expression was associated with higher MYO1E DNA methylation. Late stages of lung cancer showed significantly lower MYO1E DNA methylation and significantly higher MYO1E RNA expression for LUAD but not for LUSC. Low DNA methylation as well as high RNA expression of MYO1E are associated with a shorter median survival time and an increased risk of mortality for LUAD, but not for LUSC. This study suggests that changes in MYO1E methylation and expression in LUAD patients may have an essential role in lung cancer's pathogenesis. It shows the utility of MYO1E DNA methylation and RNA expression in predicting survival for LUAD patients. Also, given the low normal expression of MYO1E in blood cells MYO1E DNA methylation has the potential to be used as circulating tumor marker in liquid biopsies.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje