DDX47 untangles R-loops with only certain other helicases.

Autor: Yu Z; Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec H3T 1E2, Canada; Gerald Bronfman Department of Oncology McGill University, Montréal, Québec H3T 1E2, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3T 1E2, Canada; Department of Human Genetics McGill University, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada., Richard S; Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, Québec H3T 1E2, Canada; Gerald Bronfman Department of Oncology McGill University, Montréal, Québec H3T 1E2, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3T 1E2, Canada; Department of Human Genetics McGill University, Montréal, Québec H3T 1E2, Canada; Department of Medicine, McGill University, Montréal, Québec H3T 1E2, Canada. Electronic address: stephane.richard@mcgill.ca.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2023 May; Vol. 33 (5), pp. 359-360. Date of Electronic Publication: 2023 Mar 11.
DOI: 10.1016/j.tcb.2023.03.001
Abstrakt: R-loops, formed transiently during gene transcription, are tightly controlled to avoid conflict with ongoing processes. Marchena-Cruz et al. identified DExD/H box RNA helicase DDX47 using a new R-loop resolving screen and defined a unique role for this helicase in nucleolar R-loops and its interplay with senataxin (SETX) and DDX39B.
Competing Interests: Declaration of interests No interests are declared.
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Databáze: MEDLINE
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