Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.

Autor:	Akbulut AC; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Arisz RA; Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Baaten CCFMJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany., Baidildinova G; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Barakzie A; Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Bauersachs R; Cardioangiologisches Centrum Bethanien - CCB, Gefäß-Centrum, Frankfurt am Main, Germany., Ten Berg J; Department of Cardio-Thoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., van den Broek WWA; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands., de Boer HC; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands., Bonifay A; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France.; Department of Hematology and Vascular Biology, CHU La TIMONE, APHM, Marseille, France., Bröker V; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Buka RJ; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Ten Cate H; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht, The Netherlands., Ten Cate-Hoek AJ; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht, The Netherlands., Cointe S; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France.; Department of Hematology and Vascular Biology, CHU La TIMONE, APHM, Marseille, France., De Luca C; Laboratory of Morphology of Neuronal Networks and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli,' Napoli, Italy., De Simone I; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Diaz RV; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Dignat-George F; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France.; Department of Hematology and Vascular Biology, CHU La TIMONE, APHM, Marseille, France., Freson K; Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Gazzaniga G; Department of Cardio-Thoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.; Department of Clinical-Surgical, Diagnostic and Pediatric Science, University of Pavia, Pavia, Italy., van Gorp ECM; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands., Habibi A; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Henskens YMC; Central Diagnostic Laboratory, Unit for Hemostasis and Transfusion, Maastricht University Medical Centre + , Maastricht, The Netherlands., Iding AFJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht, The Netherlands., Khan A; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom.; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine and National Institute of Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Koenderink GH; Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, The Netherlands., Konkoth A; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Lacroix R; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France.; Department of Hematology and Vascular Biology, CHU La TIMONE, APHM, Marseille, France., Lahiri T; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Lam W; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States., Lamerton RE; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Lorusso R; Department of Cardio-Thoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Luo Q; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Maas C; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., McCarty OJT; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, United States., van der Meijden PEJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht, The Netherlands., Meijers JCM; Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.; Department of Experimental Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Mohapatra AK; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Nevo N; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Immunology, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Robles AP; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Poncelet P; R and T Department, BioCytex, Marseille, France., Reinhardt C; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Ruf W; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Saraswat R; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Schönichen C; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Schutgens R; Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, UMC Utrecht, University Utrecht, Utrecht, The Netherlands., Simioni P; General Internal Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padua University Hospital and University of Padua Medical School, Padua, Italy., Spada S; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Spronk HMH; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht, The Netherlands., Tazhibayeva K; Cancer Center of Shymkent, Al-Farabi Kazakh National University, Almaty, Kazakhstan., Thachil J; Department of Haematology, Manchester University Hospitals, Manchester, United Kingdom., Diaz RV; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Vallier L; Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France., Veninga A; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Verhamme P; Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium., Visser C; Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Watson SP; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom., Wenzel P; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., Willems RAL; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Willers A; Department of Cardio-Thoracic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Zhang P; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany.; Leibniz Institute for Analytical Sciences - ISAS-e.V., Dortmund, Germany., Zifkos K; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Mainz, Germany., van Zonneveld AJ; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	Thrombosis and haemostasis [Thromb Haemost] 2023 Aug; Vol. 123 (8), pp. 808-839. Date of Electronic Publication: 2023 Mar 13.
DOI:	10.1055/a-2052-9175
Abstrakt:	The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis. Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infection-associated coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies. This theme included state-of-the-art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: the value and limitations of ex vivo models. Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularized organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation-associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management. Plenary presentations addressed controversial areas, i.e., thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies, and clinically tested factor XI(a) inhibitors, both possibly with reduced bleeding risk. Finally, COVID-19-associated coagulopathy is revisited. Competing Interests: None declared. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu