Resveratrol Preconditioning Mitigates Ischemia-Induced Septal Cholinergic Cell Loss and Memory Impairments.

Autor:	López-Morales MA; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Escobar I; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Saul I; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Jackson CW; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Ferrier FJ; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Fagerli EA; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Raval AP; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Dave KR; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL., Perez-Pinzon MA; Peritz Scheinberg Cerebral Vascular Disease Research Laboratories (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Department of Neurology (M.A.L.-M., I.E., I.S., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.; Neuroscience Program (I.E., C.W.J., F.J.F., E.A.F., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.
Jazyk:	angličtina
Zdroj:	Stroke [Stroke] 2023 Apr; Vol. 54 (4), pp. 1099-1109. Date of Electronic Publication: 2023 Mar 13.
DOI:	10.1161/STROKEAHA.122.040899
Abstrakt:	Background: Cholinergic cells originating from the nuclei of the basal forebrain (BF) are critical for supporting various memory processes, yet BF cholinergic cell viability has not been explored in the context of focal cerebral ischemia. In the present study, we examined cell survival within several BF nuclei in rodents following transient middle cerebral artery occlusion. We tested the hypothesis that a previously established neuroprotective therapy-resveratrol preconditioning-would rescue BF cell loss, deficits in cholinergic-related memory performance, and hippocampal synaptic dysfunction after focal cerebral ischemia. Methods: Adult (2-3-month old) male Sprague-Dawley rats or wild-type C57Bl/6J mice were injected intraperitoneally with a single dose of resveratrol or vehicle and subjected to transient middle cerebral artery occlusion using the intraluminal suture method 2 days later. Histopathological, behavioral, and electrophysiological outcomes were measured 1-week post-reperfusion. Animals with reduction in cerebral blood flow <30% of baseline were excluded. Results: Cholinergic cell loss was observed in the medial septal nucleus and diagonal band of Broca following transient middle cerebral artery occlusion. This effect was prevented by resveratrol preconditioning, which also ameliorated transient middle cerebral artery occlusion-induced deficits in cognitive performance and hippocampal long-term potentiation. Conclusions: We demonstrate for the first time that focal cerebral ischemia induces cholinergic cell death within memory-relevant nuclei of the BF. The preservation of cholinergic cell viability may provide a mechanism by which resveratrol preconditioning improves memory performance and preserves functionality of memory-processing brain structures after focal cerebral ischemia.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu