Indirect Mechanisms of Transcription Factor-Mediated Gene Regulation during Cell Fate Changes.

Autor: Larcombe MR; Department of Anatomy and Developmental Biology Monash University Clayton Victoria 3168 Australia.; Development and Stem Cells Program Monash Biomedicine Discovery Institute Clayton Victoria 3168 Australia.; Australian Regenerative Medicine Institute Monash University Clayton Victoria 3168 Australia., Hsu S; Department of Anatomy and Developmental Biology Monash University Clayton Victoria 3168 Australia.; Development and Stem Cells Program Monash Biomedicine Discovery Institute Clayton Victoria 3168 Australia.; Australian Regenerative Medicine Institute Monash University Clayton Victoria 3168 Australia., Polo JM; Department of Anatomy and Developmental Biology Monash University Clayton Victoria 3168 Australia.; Development and Stem Cells Program Monash Biomedicine Discovery Institute Clayton Victoria 3168 Australia.; Australian Regenerative Medicine Institute Monash University Clayton Victoria 3168 Australia.; South Australian Immunogenomics Cancer Institute, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia 5005 Australia.; Adelaide Centre for Epigenetics, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia 5005 Australia., Knaupp AS; Department of Anatomy and Developmental Biology Monash University Clayton Victoria 3168 Australia.; Development and Stem Cells Program Monash Biomedicine Discovery Institute Clayton Victoria 3168 Australia.; Australian Regenerative Medicine Institute Monash University Clayton Victoria 3168 Australia.
Jazyk: angličtina
Zdroj: Advanced genetics (Hoboken, N.J.) [Adv Genet (Hoboken)] 2022 Nov 09; Vol. 3 (4), pp. 2200015. Date of Electronic Publication: 2022 Nov 09 (Print Publication: 2022).
DOI: 10.1002/ggn2.202200015
Abstrakt: Transcription factors (TFs) are the master regulators of cellular identity, capable of driving cell fate transitions including differentiations, reprogramming, and transdifferentiations. Pioneer TFs recognize partial motifs exposed on nucleosomal DNA, allowing for TF-mediated activation of repressed chromatin. Moreover, there is evidence suggesting that certain TFs can repress actively expressed genes either directly through interactions with accessible regulatory elements or indirectly through mechanisms that impact the expression, activity, or localization of other regulatory factors. Recent evidence suggests that during reprogramming, the reprogramming TFs initiate opening of chromatin regions rich in somatic TF motifs that are inaccessible in the initial and final cellular states. It is postulated that analogous to a sponge, these transiently accessible regions "soak up" somatic TFs, hence lowering the initial barriers to cell fate changes. This indirect TF-mediated gene regulation event, which is aptly named the "sponge effect," may play an essential role in the silencing of the somatic transcriptional network during different cellular conversions.
Competing Interests: The authors declare no conflict of interest.
(© 2022 The Authors. Advanced Genetics published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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