Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study.
| Autor: | Athikarisamy SE; Neonatal Directorate, Child and Adolescent Health Service, Perth, WA, Australia.; School of Medicine, University of Western Australia, Crawley, WA, Australia., Lam GC; Department of Ophthalmology, Perth Children's Hospital, Perth, WA, Australia.; Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, WA, Australia., Cooper MN; Wesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Strunk T; Neonatal Directorate, Child and Adolescent Health Service, Perth, WA, Australia.; School of Medicine, University of Western Australia, Crawley, WA, Australia.; Wesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in pediatrics [Front Pediatr] 2023 Feb 23; Vol. 11, pp. 1099614. Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023). |
| DOI: | 10.3389/fped.2023.1099614 |
| Abstrakt: | Aim: Retinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP. Methods: A retrospective study of infants (<30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia. Results: A total of 878 infants were included in this study (ROP stage 0-2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP: mild chorioamnionitis OR=0.43 (95% CI: 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI: 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR: 5.16; p < 0.001), exposure to postnatal steroids (OR: 6.65; p < 0.001), and receipt of platelet transfusion (OR: 8.21; p < 0.001). Conclusion: Maternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Athikarisamy, Lam, Cooper and Strunk.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|