Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population.
| Autor: | Darbas S; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Inan D; Department of Infectious Diseases, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Kilinc Y; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Arslan HS; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Ucar F; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Boylubay O; Isparta Provincial Health Directorate Central Community Health Center, Isparta, Turkiye., Koksoy S; Department of Medical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Mutlu E; Department of Medical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkiye., Yucel B; Department of Medical Biology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkiye., Ekinci NS; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkiye. |
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| Jazyk: | angličtina |
| Zdroj: | Northern clinics of Istanbul [North Clin Istanb] 2022 Dec 13; Vol. 10 (1), pp. 67-73. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2023). |
| DOI: | 10.14744/nci.2021.00018 |
| Abstrakt: | Objective: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among different racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye. Methods: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by sequence-based high-resolution typing. Results: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant. Conclusion: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection. Competing Interests: No conflict of interest was declared by the authors. (© Copyright 2023 by Istanbul Provincial Directorate of Health.) |
| Databáze: | MEDLINE |
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