Cytogenetic profile of adult AML patients in Turkey: a single center study with comprehensive comparison with literature.

Autor:	Cirakoglu A; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology., Kuru RD; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology., Yilmaz S; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology., Deviren A; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology., Ongoren S; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Yalniz FF; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Keskin D; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Eskazan AE; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Salihoglu A; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Cem Ar M; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Sahin S; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Aydin Y; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Hacihanefioglu S; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology., Baslar Z; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Soysal T; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Internal Medicine, Division of Hematology., Arguden YT; Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Biology.
Jazyk:	angličtina
Zdroj:	African health sciences [Afr Health Sci] 2022 Sep; Vol. 22 (3), pp. 183-191.
DOI:	10.4314/ahs.v22i3.21
Abstrakt:	Background: Cytogenetic findings are important prognostic factors in acute myeloid leukemia. Large systematic data about chromosomal characteristics of Turkish AML patients have not been reported to date. Objectives: The karyotypic profiles of 157 adult AML patients were evaluated retrospectively and compared with other reports from different populations. Methods: Cytogenetics analyses were performed on bone marrow samples using G-banding. Patients were categorized according to their cytogenetic results into four groups with the addition of a normal karyotyped group to the favorable, intermediate and adverse groups of European Leukemia Network. Results: Cytogenetic analyses were carried out successfully in 138 patients (88%). Abnormal karyotypes were found in 79 (57.2%) patients of which 13 (9.4%) were in favorable, 37 (26.8%) in intermediate and 29 (21%) in adverse groups. t(8;21) (5%) was the most common favorable abnormality while monosomal karyotypes (15.9%) in adverse group. Conclusion: This single center study is the most comprehensive study about the cytogenetic profile of acute myeloid leukemia in Turkey with comparison of other population-based studies. While there were similarities and differences with different publications, our results did not show a marked tendency to the findings of any specific geographic region. (© 2022 Cirakoglu A et al.)
Databáze:	MEDLINE
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