The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi-center study.

Autor: Khoo XH; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Chong CW; School of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia., Talha AM; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Philip K; Institute of Ocean and Earth Sciences, Universiti Malaya, Kuala Lumpur, Malaysia.; Institute of Computer Science and Digital Innovation, UCSI University, Kuala Lumpur, Malaysia., Teh CS; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Isa AM; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.; GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia., Wong MS; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.; GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia., Chew DC; Department of Medicine, Faculty of Medicine, Gastroenterology and Hepatology Unit, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Wong Z; Department of Medicine, Faculty of Medicine, Gastroenterology and Hepatology Unit, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Jusoh NS; Department of Dietetics, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia., Maksum NMM; Department of Dietetics, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia., Mokhtar NM; Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.; Faculty of Medicine, GUT Research Group, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Majid HA; Department of Social and Preventive Medicine. Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.; Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, Malaysia., Ali RAR; Department of Medicine, Faculty of Medicine, Gastroenterology and Hepatology Unit, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Lee YY; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.; GI Function and Motility Unit, Hospital Universiti Sains Malaysia, Kota Bharu, Malaysia., Mahadeva S; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2023 Aug; Vol. 38 (8), pp. 1259-1268. Date of Electronic Publication: 2023 Mar 23.
DOI: 10.1111/jgh.16174
Abstrakt: Background and Aim: The gut microbiota in irritable bowel syndrome (IBS) is known to vary with diet. We aim to (i) analyze the gut microbiota composition of IBS patients from a multi-ethnic population and (ii) explore the impact of a low FODMAP diet on gastrointestinal symptoms and gut microbiota composition among IBS patients.
Methods: A multi-center study of multi-ethnic Asian patients with IBS was conducted in two phases: (i) an initial cross-sectional gut microbiota composition study of IBS patients and healthy controls, followed by (ii) a single-arm 6-week dietary interventional study of the IBS patients alone, exploring clinical and gut microbiota changes.
Results: A total of 34 adult IBS patients (IBS sub-types of IBS-D 44.1%, IBS-C 32.4%, and IBS-M 23.5%) and 15 healthy controls were recruited. A greater abundance of Parabacteroides species with lower levels of bacterial fermenters and short-chain fatty acids producers were found among IBS patients compared with healthy controls. Age and ethnicity were found to be associated with gut microbiota composition. Following a low FODMAP dietary intervention, symptom and quality of life improvement were observed in 24 (70.6%) IBS patients. Symptom improvement was associated with adherence to the low FODMAP diet (46.7% poor adherence vs 92.9% good adherence, P = 0.014), and gut microbiota patterns, particularly with a greater abundance of Bifidobacterium longum, Anaerotignum propionicum, and Blautia species post-intervention.
Conclusion: Gut microbiota variation in multi-ethnic IBS patients may be related to dietary intake and may be helpful to identify patients who are likely to respond to a low FODMAP diet.
(© 2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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