Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study.

Autor: Marti-Marti I; Department of Dermatology, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Electronic address: ignasi.marti.marti@gmail.com., Podlipnik S; Department of Dermatology, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain., Cañueto J; Department of Dermatology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain., Ferrándiz-Pulido C; Department of Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Deza G; Department of Dermatology, Hospital del Mar, Barcelona, Spain., Sanmartín O; Department of Dermatology, Instituto Valenciano de Oncología, Valencia, Spain., Jaka A; Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain., Beà-Ardèbol S; Department of Dermatology, Hospital Universitario Ramón y Cajal, Madrid, Spain., Botella-Estrada R; Department of Dermatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Redondo P; Department of Dermatology, Clinica Universidad de Navarra, Pamplona/Madrid, Spain., Turrión-Merino L; Department of Dermatology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain., Ruiz-Salas V; Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Masferrer E; Department of Dermatology, Hospital Universitari Mútua de Terrassa, Terrassa, Spain., Yébenes M; Department of Dermatology, Consorci Corporació Sanitària Parc Taulí, Sabadell, Spain., Sánchez-Schmidt JM; Department of Dermatology, Hospital General de Granollers, Granollers, Spain., Gracia-Darder I; Department of Dermatology, Hospital Universitari Son Espases, Palma, Spain., Altemir-Vidal A; Department of Dermatology, Hospital Universitari Sagrat Cor, Barcelona, Spain., Aguayo-Ortiz RS; Department of Dermatology, Hospital Universitari Arnau de Vilanova, Lleida, Spain., Becerril S; Department of Dermatology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain., Bodet-Castillo D; Department of Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Leal L; Department of Dermatology, Hospital del Mar, Barcelona, Spain., Fuente MJ; Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain., Moreno-Arrones OM; Department of Dermatology, Hospital Universitario Ramón y Cajal, Madrid, Spain., Abril-Pérez C; Department of Dermatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Tomás-Velázquez A; Department of Dermatology, Clinica Universidad de Navarra, Pamplona/Madrid, Spain., Sandoval-Clavijo A; Department of Dermatology, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain., Toll A; Department of Dermatology, Hospital Clinic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2023 Jul; Vol. 89 (1), pp. 119-127. Date of Electronic Publication: 2023 Mar 10.
DOI: 10.1016/j.jaad.2023.02.048
Abstrakt: Background: Satellitosis or in-transit metastasis (S-ITM) has clinical outcomes comparable to node-positivity in cutaneous squamous cell carcinoma (cSCC). There is a need to stratify the risk groups.
Objective: To determine which prognostic factors of S-ITM confer an increased risk of relapse and cSCC-specific-death.
Methods: A retrospective, multicenter cohort study. Patients with cSCC developing S-ITM were included. Multivariate competing risk analysis evaluated which factors were associated with relapse and specific death.
Results: Of a total of 111 patients with cSCC and S-ITM, 86 patients were included for analysis. An S-ITM size of ≥20 mm, >5 S-ITM lesions, and a primary tumor deep invasion was associated with an increased cumulative incidence of relapse (subhazard ratio [SHR]: 2.89 [95% CI, 1.44-5.83; P = .003], 2.32 [95% CI, 1.13-4.77; P = .021], and 2.863 [95% CI, 1.25-6.55; P = .013]), respectively. Several >5 S-ITM lesions were also associated with an increased probability of specific death (SHR: 3.48 [95% CI, 1.18-10.2; P = .023]).
Limitations: Retrospective study and heterogeneity of treatments.
Conclusion: The size and the number of S-ITM lesions confer an increased risk of relapse and the number of S-ITM an increased risk of specific-death in patients with cSCC presenting with S-ITM. These results provide new prognostic information and can be considered in the staging guidelines.
Competing Interests: Conflicts of interest The authors have no conflicts of interest to declare.
(Copyright © 2023 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: