The role of dietary strategies in the modulation of hallmarks of aging.

Autor: Grande de França NA; Gérontopôle of Toulouse, Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France. Electronic address: natasha.agf@gmail.com., Rolland Y; Gérontopôle of Toulouse, Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; Maintain Aging Researchteam, CERPOP, Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France., Guyonnet S; Gérontopôle of Toulouse, Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; Maintain Aging Researchteam, CERPOP, Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France., de Souto Barreto P; Gérontopôle of Toulouse, Institute on Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France; Maintain Aging Researchteam, CERPOP, Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2023 Jun; Vol. 87, pp. 101908. Date of Electronic Publication: 2023 Mar 10.
DOI: 10.1016/j.arr.2023.101908
Abstrakt: The hallmarks of aging constitute an interconnected network of basic mechanisms that modulate aging and can be modulated by lifestyle factors, including dietary strategies. This narrative review aimed to summarize the evidence on promoting dietary restriction or adherence to specific dietary patterns on hallmarks of aging. Studies with preclinical models or humans were considered. Dietary restriction (DR), usually operationalized as a reduction in caloric intake, is the main strategy applied to study the axis diet-hallmarks of aging. DR has been shown to modulate mainly genomic instability, loss of proteostasis, deregulating nutrient sensing, cellular senescence, and altered intercellular communication. Much less evidence exists on the role of dietary patterns, with most of the studies evaluating the Mediterranean Diet and other similar plant-based diets, and the ketogenic diet. Potential benefits are described in genomic instability, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, and altered intercellular communication. Given the predominant place of food in human life, it is imperative to determine the impact of nutritional strategies on the modulation of lifespan and healthspan, considering applicability, long-term adherence, and side effects.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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