Fourier-Transform Infrared Spectroscopy as a Screening Tool for Osteosarcopenia in Community-Dwelling Older Women.

Autor:	Freitas RVM; Postgraduation Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil., de Freitas DLD; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, Brazil., de Oliveira IRD; Postgraduation Program in Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil., Dos Santos Gomes C; Department of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil., Guerra GCB; Department of Pharmacology and Biophysics, Federal University of Rio Grande do Norte, Natal, Brazil., Dantas PMS; Postgraduation Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduation Program in Physical Education, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva TG; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, Brazil., Duque G; Department of Medicine, McGill University, Montreal, Quebec, Canada.; Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., de Lima KMG; Institute of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal, Brazil., Guerra RO; Postgraduation Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduation Program in Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2023 Aug 27; Vol. 78 (9), pp. 1543-1549.
DOI:	10.1093/gerona/glad081
Abstrakt:	Osteosarcopenia is a complex geriatric syndrome characterized by the presence of both sarcopenia and osteopenia/osteoporosis. This condition increases rates of disability, falls, fractures, mortality, and mobility impairments in older adults. The purpose of this study was to analyze the Fourier-transform infrared (FTIR) spectroscopy diagnostic power for osteosarcopenia in community-dwelling older women (n = 64; 32 osteosarcopenic and 32 non-osteosarcopenia). FTIR is a fast and reproducible technique highly sensitive to biological tissues, and a mathematical model was created using multivariate classification techniques that denoted the graphic spectra of the molecular groups. Genetic algorithm and support vector machine regression (GA-SVM) was the most feasible model, achieving 80.0% of accuracy. GA-SVM identified 15 wave numbers responsible for class differentiation, in which several amino acids (responsible for the proper activation of the mammalian target of rapamycin) and hydroxyapatite (an inorganic bone component) were observed. Imaging tests and low availability of instruments that allow the observation of osteosarcopenia involve high health costs for patients and restrictive indications. Therefore, FTIR can be used to diagnose osteosarcopenia due to its efficiency and low cost and to enable early detection in geriatric services, contributing to advances in science and technology that are potential "conventional" methods in the future. (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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