Ovarian Cancer and Glutamine Metabolism.

Autor: Fasoulakis Z; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Koutras A; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Ntounis T; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Prokopakis I; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Perros P; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Chionis A; Department of Obstetrics and Gynecology, Laiko General Hospital of Athens, Agiou Thoma 17, 11527 Athens, Greece., Sapantzoglou I; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Katrachouras A; Department of Obstetrics and Gynecology, University General Hospital of Ioannina, University of Ioannina, Stavrou Niarchou Str., 45500 Ioannina, Greece., Konis K; Department of Obstetrics and Gynecology, General Hospital of Arta, Lofos Peranthis, 47100 Arta, Greece., Samara AA; Department of Embryology, University Hospital of Larissa, Mezourlo, 41110 Larissa, Greece., Valsamaki A; Department of Internal Medicine, General Hospital of Larisa, Tsakalof 1, 41221 Larisa, Greece., Palios VC; Department of Obstetrics and Gynecology, University General Hospital of Larissa, Mezourlo, 41110 Larissa, Greece., Symeonidis P; Department of Obstetrics and Gynecology, University General Hospital of Alexandroupolis, 6th klm Alexandroupolis-Makris, Dragana Alexandroupolis, 68100 Alexandroupolis, Greece., Nikolettos K; Department of Obstetrics and Gynecology, Democritus University of Thrace, 6th km Alexandroupolis-Makris, 68100 Alexandroupolis, Greece., Pagkalos A; Department of Obstetrics and Gynecology, General Hospital of Xanthi, Neapoli, 67100 Xanthi, Greece., Sotiriou S; Department of Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, Greece., Theodora M; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Antsaklis P; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Daskalakis G; 1st Department of Obstetrics and Gynecology, General Hospital of Athens 'ALEXANDRA', National and Kapodistrian University of Athens, Lourou and Vasilissis Sofias Ave, 11528 Athens, Greece., Kontomanolis EN; Department of Obstetrics and Gynecology, Democritus University of Thrace, 6th km Alexandroupolis-Makris, 68100 Alexandroupolis, Greece.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 06; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 06.
DOI: 10.3390/ijms24055041
Abstrakt: Cancer cells are known to have a distinct metabolic profile and to exhibit significant changes in a variety of metabolic mechanisms compared to normal cells, particularly glycolysis and glutaminolysis, in order to cover their increased energy requirements. There is mounting evidence that there is a link between glutamine metabolism and the proliferation of cancer cells, demonstrating that glutamine metabolism is a vital mechanism for all cellular processes, including the development of cancer. Detailed knowledge regarding its degree of engagement in numerous biological processes across distinct cancer types is still lacking, despite the fact that such knowledge is necessary for comprehending the differentiating characteristics of many forms of cancer. This review aims to examine data on glutamine metabolism and ovarian cancer and identify possible therapeutic targets for ovarian cancer treatment.
Databáze: MEDLINE
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