| Autor: |
Galizzi G; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), CNR, via U. La Malfa 153, 90146 Palermo, Italy., Deidda I; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), CNR, via U. La Malfa 153, 90146 Palermo, Italy., Amato A; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università Degli Studi di Palermo, Viale Delle Scienze, 90128 Palermo, Italy., Calvi P; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università Degli Studi di Palermo, Viale Delle Scienze, 90128 Palermo, Italy.; Dipartimento di Biomedicina, Neuroscienze, e Diagnostica Avanzata (Bi.N.D) (sez. Anatomia Umana), Università di Palermo, via del Vespro 129, 90127 Palermo, Italy., Terzo S; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università Degli Studi di Palermo, Viale Delle Scienze, 90128 Palermo, Italy., Caruana L; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), CNR, via U. La Malfa 153, 90146 Palermo, Italy., Scoglio S; Centro di Ricerche Nutriterapiche, 61029 Urbino, Italy., Mulè F; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università Degli Studi di Palermo, Viale Delle Scienze, 90128 Palermo, Italy., Di Carlo M; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), CNR, via U. La Malfa 153, 90146 Palermo, Italy. |
| Abstrakt: |
Obesity and related metabolic dysfunctions are associated with neurodegenerative diseases, such as Alzheimer's disease. Aphanizomenon flos-aquae (AFA) is a cyanobacterium considered a suitable supplement for its nutritional profile and beneficial properties. The potential neuroprotective effect of an AFA extract, commercialized as KlamExtra ® , including the two AFA extracts Klamin ® and AphaMax ® , in High-Fat Diet (HFD)-fed mice was explored. Three groups of mice were provided with a standard diet (Lean), HFD or HFD supplemented with AFA extract (HFD + AFA) for 28 weeks. Metabolic parameters, brain insulin resistance, expression of apoptosis biomarkers, modulation of astrocytes and microglia activation markers, and Aβ deposition were analyzed and compared in the brains of different groups. AFA extract treatment attenuated HFD-induced neurodegeneration by reducing insulin resistance and loss of neurons. AFA supplementation improved the expression of synaptic proteins and reduced the HFD-induced astrocytes and microglia activation, and Aβ plaques accumulation. Together, these outcomes indicate that regular intake of AFA extract could benefit the metabolic and neuronal dysfunction caused by HFD, decreasing neuroinflammation and promoting Aβ plaques clearance. |
