| Autor: |
Titu S; Faculty of Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania.; Department of Surgical Oncology, The Oncology Institute 'Prof. Dr. Ion Chiricuta' Cluj-Napoca, 400015 Cluj-Napoca, Romania., Gata VA; Department of Surgical Oncology, The Oncology Institute 'Prof. Dr. Ion Chiricuta' Cluj-Napoca, 400015 Cluj-Napoca, Romania.; Department of Oncological Surgery and Gynecological Oncology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Decea RM; Department of Physiology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Mocan T; Faculty of Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania.; Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology, 400126 Cluj-Napoca, Romania., Dina C; Faculty of Medicine, Ovidius University, 900527 Constanta, Romania., Irimie A; Faculty of Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400126 Cluj-Napoca, Romania.; Department of Surgical Oncology, The Oncology Institute 'Prof. Dr. Ion Chiricuta' Cluj-Napoca, 400015 Cluj-Napoca, Romania., Lisencu CI; Department of Surgical Oncology, The Oncology Institute 'Prof. Dr. Ion Chiricuta' Cluj-Napoca, 400015 Cluj-Napoca, Romania.; Department of Oncological Surgery and Gynecological Oncology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. |
| Abstrakt: |
Exosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways. Certain types of mediators derived from cancer cells can play a crucial role in the development of this pathology, promoting tumor growth, invasion, metastasis, angiogenesis, and immunomodulation. Exosomes in the bloodstream show promise as a future tool for detecting cancer at an early stage. The sensitivity and specificity of clinical exosome biomarkers need to be enhanced. Knowledge of exosomes is not only important for understanding the significance of cancer progression but also for providing clinicians with useful information for the diagnosis, treatment, and discovery of methods to prevent cancer from recurring. The widespread adoption of diagnostic tools based on exosomes may revolutionize cancer diagnosis and treatment. Tumor metastasis, chemoresistance, and immunity are all aided by exosomes. A potential new approach to cancer therapy involves preventing metastasis by inhibiting miRNA intracellular signaling and blocking the formation of pre-metastatic niches. For colorectal patients, exosomes represent a promising area of investigation for improving the diagnosis, treatment, and management. Reported data demonstrate that the serum expression level of certain exosomal miRNA is significantly higher in primary colorectal cancer patients. The present review discusses mechanisms and clinical implications of exosomes in colorectal cancer. |
