Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol.

Autor:	de Paz-Silava SLM; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Medical Microbiology, College of Public Health, University of the Philippines Manila, Manila 1000, Philippines., Tabios IKB; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City 1101, Philippines., Tantengco OAG; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Physiology, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Biology, College of Science, De La Salle University, Manila 0922, Philippines., Climacosa FMM; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Medical Microbiology, College of Public Health, University of the Philippines Manila, Manila 1000, Philippines., Velayo CL; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Physiology, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of the Philippines College of Medicine-Philippine General Hospital, University of the Philippines Manila, Manila 1000, Philippines., Lintao RCV; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines., Cando LFT; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines., Perias GAS; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines., Idolor MIC; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines., Francisco AG; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Medical Microbiology, College of Public Health, University of the Philippines Manila, Manila 1000, Philippines., Catral CDM; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines., Chiong CM; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Otolaryngology-Head and Neck Surgery, University of the Philippines College of Medicine-Philippine General Hospital, Manila 1000, Philippines., Dalmacio LMM; Multi-Omics Research Program for Health, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.; Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.
Jazyk:	angličtina
Zdroj:	Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2023 Feb 23; Vol. 11 (5). Date of Electronic Publication: 2023 Feb 23.
DOI:	10.3390/healthcare11050658
Abstrakt:	HPV infection is one of the most studied risk factors in cervical cancer-the second most common cancer site and cause of death due to cancer in the Philippines. However, there is a lack of population-based epidemiological data on cervical HPV infection in the Philippines. Local reports on co-infections with other lower genital tract pathogens, commonly reported globally, are also lacking, which emphasizes the need to increase efforts in targeting HPV prevalence, genotype, and distribution. Hence, we aim to determine the molecular epidemiology and natural history of HPV infection among reproductive-age Filipino women using a community-based prospective cohort design. Women from rural and urban centers will be screened until the target sample size of 110 HPV-positive women (55 from rural sites and 55 from urban sites) is reached. Cervical and vaginal swabs will be collected from all screened participants. For HPV-positive patients, HPV genotypes will be determined. One hundred ten healthy controls will be selected from previously screened volunteers. The cases and controls will comprise the multi-omics subset of participants and will be followed up after 6 and 12 months for repeat HPV screening. Metagenomic and metabolomic analyses of the vaginal swabs will also be performed at baseline, after 6 months, and after 12 months. The results of this study will update the prevalence and genotypic distribution of cervical HPV infection among Filipino women, determine whether the current vaccines used for HPV vaccination programs capture the most prevalent high-risk HPV genotypes in the country, and identify vaginal community state types and bacterial taxa associated with the natural history of cervical HPV infection. The results of this study will be used as the basis for developing a biomarker that can help predict the risk of developing persistent cervical HPV infection in Filipino women.
Databáze:	MEDLINE
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