COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study.

Autor: Martínez-López J; Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain., De la Cruz J; Research Institute, Hospital Universitario 12 de Octubre, imas12, 28041 Madrid, Spain., Gil-Manso R; Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain., Alegre A; Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain., Ortiz J; Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain., Llamas P; Hematology Department, Hospital Fundación Jiménez Díaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain., Martínez Y; Hematology Department, Hospital Fundación Jiménez Díaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain., Hernández-Rivas JÁ; Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain., González-Gascón I; Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain., Benavente C; Hematology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain., Estival Monteliu P; Hematology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain., Jiménez-Yuste V; Hematology Department, Hospital Universitario La Paz, 28046 Madrid, Spain., Canales M; Hematology Department, Clínica Universidad de Navarra, 28027 Madrid, Spain., Bastos M; Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.; Department of Medicine, Universidad Complutense, 28223 Madrid, Spain., Kwon M; Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.; Department of Medicine, Universidad Complutense, 28223 Madrid, Spain., Valenciano S; Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain., Callejas-Charavia M; Hematology Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain., López-Jiménez J; Hematology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Herrera P; Hematology Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Duarte R; Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain., Núñez Martín-Buitrago L; Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain., Sanchez Godoy P; Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain., Jacome Yerovi C; Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain., Martínez-Barranco P; Hematology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain., García Roa M; Hematology Department, Hospital Universitario Fundación Alcorcón, 28922 Madrid, Spain., Escolano Escobar C; Hematology Department, Hospital Universitario de Getafe, 28905 Madrid, Spain., Matilla A; Hematology Department, Hospital Central de la Defensa Gómez Ulla, 28047 Madrid, Spain., Rosado Sierra B; Hematology Department, Hospital Universitario Rey Juan Carlos, Móstoles, 28933 Madrid, Spain., Aláez-Usón MC; Hematology Department, Hospital HLA Universitario Moncloa, 28027 Madrid, Spain., Quiroz-Cervantes K; Hematology Department, Hospital Universitario de Móstoles, 28935 Madrid, Spain., Martínez-Chamorro C; Hematology Department, Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain., Pérez-Oteyza J; Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain., Martos-Martinez R; Hematology Department, Hospital Universitario General de Villalba, Villalba, 28400 Madrid, Spain., Herráez R; Hematology Department, Hospital Universitario Infanta Sofía, San Sebastián de Los Reyes, 28702 Madrid, Spain., González-Santillana C; Hematology Department, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain., Del Campo JF; Hematology Department, Hospital Universitario del Henares, Coslada, 28822 Madrid, Spain., Alonso A; Hematology Department, Hospital Ruber, 28006 Madrid, Spain., de la Fuente A; Hematology Department, MD Anderson Cancer Center Madrid, 28033 Madrid, Spain., Pascual A; Hematology Department, Hospital Universitario Infanta Elena, Valdemoro, 28340 Madrid, Spain., Bustelos-Rodriguez R; Hematology Department, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain., Sebrango A; Hematology Department, Hospital Universitario de Torrejón, 28850 Madrid, Spain., Ruiz E; Hematology Department, Hospital Universitario del Tajo, Aranjuez, 28300 Madrid, Spain., Marcheco-Pupo EA; Hematology Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain., Grande C; Hematology Department, Clínica Universidad de Navarra, 28027 Madrid, Spain., Cedillo Á; Asociación Madrileña de Hematología y Hemoterapia (AMHH), 28040 Madrid, Spain., Lumbreras C; Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain., Arroyo Barea A; Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain., Casas-Rojo JM; Internal Medicine Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain., Calbacho M; Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain., Diez-Martín JL; Hematology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.; Department of Medicine, Universidad Complutense, 28223 Madrid, Spain., García-Suárez J; Hematology Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Feb 27; Vol. 15 (5). Date of Electronic Publication: 2023 Feb 27.
DOI: 10.3390/cancers15051497
Abstrakt: Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February-June 2020; n = 769 (66%)) and later (July 2020-February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11-0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01-3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22-0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81-1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.
Databáze: MEDLINE
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