Association between the Processed Dietary Pattern and Tumor Staging in Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma.

Autor: Lima ACDS; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil., Ferreira TJ; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil.; Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil., Campos ADS; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil.; Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil., Matida LM; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil., Castro MBT; Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil., Freitas-Vilela AA; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil.; Special Academic Unit of Health Sciences, Federal University of Jataí, Jataí 75801-615, Brazil., Horst MA; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, Brazil.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Feb 25; Vol. 15 (5). Date of Electronic Publication: 2023 Feb 25.
DOI: 10.3390/cancers15051476
Abstrakt: Purpose: This study aimed to assess the association between dietary patterns and tumor staging and the degree of cell differentiation in patients with head and neck squamous cell carcinoma (HNSCC).
Methods: This cross-sectional study included 136 individuals newly diagnosed with different stages of HNSCC, aged 20- to 80 years-old. Dietary patterns were determined by principal component analysis (PCA), using data collected from a food frequency questionnaire (FFQ). Anthropometric, lifestyle, and clinicopathological data were collected from patients' medical records. Disease staging was categorized as initial stage (stages I and II), intermediary (stage III), and advanced (stage IV). Cell differentiation was categorized as poor, moderate, or well-differentiated. The association of dietary patterns with tumor staging and cell differentiation was evaluated using multinomial logistic regression models and adjusted for potential confounders.
Results: Three dietary patterns, "healthy," "processed," and "mixed," were identified. The "processed" dietary pattern was associated with intermediary (odds ratio (OR) 2.47; 95% confidence interval (CI) 1.43-4.26; p = 0.001) and advanced (OR 1.78; 95% CI 1.12-2.84; p = 0.015) staging. No association was found between dietary patterns and cell differentiation.
Conclusion: A high adherence to dietary patterns based on processed foods is associated with advanced tumor staging in patients newly diagnosed with HNSCC.
Databáze: MEDLINE
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