| Autor: |
Stanciu IM; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Parosanu AI; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Orlov-Slavu C; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Iaciu IC; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Popa AM; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Olaru CM; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Pirlog CF; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Vrabie RC; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania., Nitipir C; Department of Oncology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Elias University Emergency Hospital, 011461 Bucharest, Romania. |
| Abstrakt: |
The latest and newest discoveries for advanced and metastatic hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer are the three cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) in association with endocrine therapy (ET). However, even if this treatment revolutionized the world and continued to be the first-line treatment choice for these patients, it also has its limitations, caused by de novo or acquired drug resistance which leads to inevitable progression after some time. Thus, an understanding of the overview of the targeted therapy which represents the gold therapy for this subtype of cancer is essential. The full potential of CDK4/6i is yet to be known, with many trials ongoing to expand their utility to other breast cancer subtypes, such as early breast cancer, and even to other cancers. Our research establishes the important idea that resistance to combined therapy (CDK4/6i + ET) can be due to resistance to endocrine therapy, to treatment with CDK4/6i, or to both. Individuals' responses to treatment are based mostly on genetic features and molecular markers, as well as the tumor's hallmarks; therefore, a future perspective is represented by personalized treatment based on the development of new biomarkers, and strategies to overcome drug resistance to combinations of ET and CDK4/6 inhibitors. The aim of our study was to centralize the mechanisms of resistance, and we believe that our work will have utility for everyone in the medical field who wants to deepen their knowledge about ET + CDK4/6 inhibitors resistance. |
