Relationship between genetically proxied vitamin D and psoriasis risk: a Mendelian randomization study.

Autor: Bohmann P; Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany., Stein MJ; Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany., Konzok J; Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany., Tsoi LC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics and.; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Elder JT; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA., Leitzmann MF; Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany., Baumeister SE; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany., Baurecht H; Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany.
Jazyk: angličtina
Zdroj: Clinical and experimental dermatology [Clin Exp Dermatol] 2023 Jun 05; Vol. 48 (6), pp. 642-647.
DOI: 10.1093/ced/llad095
Abstrakt: Background: Observational research suggests that vitamin D levels affect psoriasis. However, observational studies are prone to potential confounding or reverse causation, which complicates interpreting the data and drawing causal conclusions.
Aim: To apply Mendelian randomization (MR) methods to comprehensively assess a potential association between vitamin D and psoriasis.
Methods: Genetic variants strongly associated with 25-hydroxyvitamin D (25OHD) in genome-wide association study (GWAS) data from 417 580 and 79 366 individuals from two independent studies served as instrumental variables (used as the discovery and replication datasets, respectively). As the outcome variable, we used GWAS data of psoriasis (13 229 people in the case group, 21 543 in the control group). We used (i) biologically validated genetic instruments, and (ii) polygenic genetic instruments to assess the relationship between genetically proxied vitamin D and psoriasis. We carried out inverse-variance weighted (IVW) MR analyses for the primary analysis. In sensitivity analyses, we used robust MR approaches.
Results: MR analyses of both the discovery and replication datasets did not show an effect of 25OHD on psoriasis. Neither the IVW MR analysis of the biologically validated instruments [discovery dataset: odds ratio (OR) 0.99; 95% confidence interval (CI) 0.88-1.12, P = 0.873; replication dataset: OR 0.98, 95% CI 0.66-1.46, P = 0.930] nor that of the polygenic genetic instruments (discovery dataset: OR 1.00, 95% CI 0.81-1.22, P = 0.973; replication dataset: OR 0.94, 95% CI 0.64-1.38, P = 0.737) revealed an impact of 25OHD on psoriasis.
Conclusion: The present MR study did not support the hypothesis that vitamin D levels, measured by 25OHD, affect psoriasis. This study was conducted on Europeans, so the conclusions may not be applicable to all ethnicities.
Competing Interests: Conflicts of interest The authors declare they have no conflicts of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze: MEDLINE
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