Genital epithelial barrier function is conserved by intravaginal rings releasing etonogestrel and ethinyl estradiol.

Autor:	Liu M; Department of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA.; Comparative Biomedical Sciences Graduate Program, OSU College of Veterinary Medicine, Columbus, OH, USA., Vicetti Miguel RD; Department of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA., Quispe Calla NE; Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Aceves KM; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA., Fritts L; California National Primate Research Center, University of California, Davis, Davis, CA, USA., Miller CJ; California National Primate Research Center, University of California, Davis, Davis, CA, USA.; Center for Comparative Medicine, University of California, Davis, Davis, CA, USA., Moss JA; Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, USA., Baum MM; Department of Chemistry, Oak Crest Institute of Science, Monrovia, CA, USA., Cherpes TL; Department of Otolaryngology - Head and Neck Surgery, The Ohio State University (OSU) College of Medicine, Columbus, OH, USA.
Jazyk:	angličtina
Zdroj:	Tissue barriers [Tissue Barriers] 2024 Jan 02; Vol. 12 (1), pp. 2186672. Date of Electronic Publication: 2023 Mar 10.
DOI:	10.1080/21688370.2023.2186672
Abstrakt:	The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring NuvaRing® is another contraceptive option that like DMPA suppresses hypothalamic pituitary ovarian (HPO) axis function with local release of progestin (etonogestrel) and estrogen (ethinyl estradiol). As we previously reported that treating mice with DMPA and estrogen averts the loss of genital epithelial integrity and barrier function induced by DMPA alone, in the current investigation we compared genital levels of the cell-cell adhesion molecule desmoglein-1 (DSG1) and genital epithelial permeability in rhesus macaques (RM) treated with DMPA or a NuvaRing®re-sized for RM (N-IVR). While these studies demonstrated comparable inhibition of the HPO axis with DMPA or N-IVR, DMPA induced significantly lower genital DSG1 levels and greater tissue permeability to intravaginally administered low molecular mass molecules. By identifying greater compromise of genital epithelial integrity and barrier function in RM administered DMPA vs. N-IVR, our results add to the growing body of evidence that indicate DMPA weakens a fundamental mechanism of anti-pathogen host defense in the female genital tract.
Databáze:	MEDLINE
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