The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine.

Autor: Kalhori MR; Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. mohammadreza.kalhori@kums.ac.ir., Soleimani M; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Alibakhshi R; Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran., Kalhori AA; Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran., Mohamadi P; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical, Sciences, Tehran, Iran.; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran., Azreh R; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Farzaei MH; Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Jazyk: angličtina
Zdroj: Stem cell reviews and reports [Stem Cell Rev Rep] 2023 Jul; Vol. 19 (5), pp. 1232-1251. Date of Electronic Publication: 2023 Mar 11.
DOI: 10.1007/s12015-023-10510-8
Abstrakt: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21. Cancer-related studies have shown that this miRNA has proto-oncogene activity and is elevated in cancers. However, it is confirmed that miR-21 inhibits stem cell pluripotency and self-renewal and induces differentiation by targeting various genes. Regenerative medicine is a field of medical science that tries to regenerate and repair damaged tissues. Various studies have shown that miR-21 plays an essential role in regenerative medicine by affecting stem cell proliferation and differentiation. In this review, we will discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs will be analyzed as potential regulators of miR-21 expression in regenerative medicine.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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