Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.

Autor: Kotsakis Ruehlmann A; University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA., Sammallahti S; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Cortés Hidalgo AP; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Bakulski KM; University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA., Binder EB; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Campbell ML; University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa., Caramaschi D; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Cecil CAM; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands., Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cruceanu C; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Czamara D; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany., Dieckmann L; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany., Dou J; University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Herberth G; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Hoang TT; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA., Houtepen LC; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Hüls A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Koen N; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; and UCT Neuroscience Institute, Cape Town, South Africa.; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA., Magnus MC; Norwegian Institute of Public Health, Centre for Fertility and Health, Oslo, Norway., Mancano G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Mulder RH; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Page CM; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway., Räikkönen K; University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland., Röder S; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Schmidt RJ; University of California-Davis, School of Medicine, Department of Public Health Sciences, Davis, CA, USA., Send TS; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sharp G; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Stein DJ; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; and UCT Neuroscience Institute, Cape Town, South Africa.; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Tuhkanen J; University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zar HJ; Department of Paediatrics & Child Health & SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa., Zenclussen AC; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Zhang Y; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Zillich L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wright R; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lahti J; University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland., Brunst KJ; University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA. Kelly.Brunst@uc.edu.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2023 Dec; Vol. 28 (12), pp. 5090-5100. Date of Electronic Publication: 2023 Mar 10.
DOI: 10.1038/s41380-023-02010-5
Abstrakt: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1 and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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