Branched chain amino acids catabolism as a source of new drug targets in pathogenic protists.

Autor: Santos Souza HF; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, 05508-000, SP, Brazil., Marsiccobetre S; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, 05508-000, SP, Brazil., Souza ROO; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, 05508-000, SP, Brazil; Pharmacology and Toxicology Department, Indiana University School of Medicine, 365 Barnhill Drive, Indianapolis, IN, 46202, USA., Luévano-Martínez LA; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, 05508-000, SP, Brazil; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud and the Institute for Obesity Research, Monterrey, 64710, Mexico., Silber AM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo, 05508-000, SP, Brazil. Electronic address: asilber@usp.br.
Jazyk: angličtina
Zdroj: Experimental parasitology [Exp Parasitol] 2023 Jun; Vol. 249, pp. 108499. Date of Electronic Publication: 2023 Mar 09.
DOI: 10.1016/j.exppara.2023.108499
Abstrakt: Leucine, isoleucine, and valine, collectively termed Branched Chain Amino Acids (BCAA), are hydrophobic amino acids (AAs) and are essential for most eukaryotes since in these organisms they cannot be biosynthesized and must be supplied by the diet. These AAs are structurally relevant for muscle cells and, of course, important for the protein synthesis process. The metabolism of BCAA and its participation in different biological processes in mammals have been relatively well described. However, for other organisms as pathogenic parasites, the literature is really scarce. Here we review the BCAA catabolism, compile evidence on their relevance for pathogenic eukaryotes with special emphasis on kinetoplastids and highlight unique aspects of this underrated pathway.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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