| Autor: |
Brasky TM; Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA., Ray RM; Women's Health Initiative, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Newton AM; Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA., Navarro SL; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Schenk JM; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Loomans-Kropp HA; Division of Cancer Prevention & Control, The Ohio State University College of Medicine, Columbus, Ohio, USA., Arthur RS; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA., Snetselaar LG; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USA., Hays J; Division of Medical Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA., Neuhouser ML; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA. |
| Abstrakt: |
B-vitamins contribute to DNA synthesis, maintenance, and regulation. Few studies have examined associations of supplemental sources of B-vitamins with the incidence of upper gastrointestinal (GI) cancers [including gastric (GCA) and esophageal (ECA) cancers]; the only prior study to comprehensively examine such intakes reported potential elevated risks of ECA. We examined 159,401 postmenopausal women, ages 50-79 years at baseline, including 302 incident GCA and 183 incident ECA cases, over 19 years of follow-up within the Women's Health Initiative observational study and clinic trials. Adjusted Cox regression models estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations of supplemental B-vitamins [riboflavin (B 2 ), pyridoxine (B 6 ), folic acid (B 9 ), or cobalamin (B 12 )] with GCA and ECA risk, respectively. Although HRs were generally below 1.0, we observed no statistically significant associations between supplemental intakes of any of the evaluated B-vitamins with the risk of GCA or ECA. As the first prospective study to comprehensively assess these associations, our findings do not corroborate prior research indicating potential harm from supplemental B-vitamin intake for upper GI cancer risk. This study adds evidence that supplemental intakes of B-vitamins may be used by postmenopausal women without regard to their relationship with upper GI cancer risk. |
