Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission.

Autor: Wan J; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Liang Q; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Zhang R; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Cheng Y; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Wang X; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Wang H; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Zhang J; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Jia D; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Du Y; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Zheng W; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Tang D; State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China., Wei T; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China. weitaiyun@fafu.edu.cn., Chen Q; Vector-Borne Virus Research Center, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China. chenqian@fafu.edu.cn.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Mar 09; Vol. 14 (1), pp. 1289. Date of Electronic Publication: 2023 Mar 09.
DOI: 10.1038/s41467-023-36993-0
Abstrakt: Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring for long-term viral persistence in nature, but the mechanism remains largely unknown. Here, we identify the sperm-specific serpin protein HongrES1 of leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus Rice gall dwarf virus (RGDV) and a previously undescribed symbiotic virus of the Virgaviridae family, Recilia dorsalis filamentous virus (RdFV). We show that HongrES1 mediates the direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with both viral capsid proteins. Direct interaction of viral capsid proteins mediates simultaneously invasion of two viruses into male reproductive organs. Moreover, arbovirus activates HongrES1 expression to suppress the conversion of prophenoloxidase to active phenoloxidase, potentially producing a mild antiviral melanization defense. Paternal virus transmission scarcely affects offspring fitness. These findings provide insights into how different viruses cooperatively hijack insect sperm-specific proteins for paternal transmission without disturbing sperm functions.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: