Ketone Monoester Plus Carbohydrate Supplementation Does Not Alter Exogenous and Plasma Glucose Oxidation or Metabolic Clearance Rate During Exercise in Men Compared with Carbohydrate Alone.

Autor: Howard EE; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States., Allen JT; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States., Coleman JL; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States; Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States., Small SD; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States; Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States; Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada., Karl JP; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States., O'Fallon KS; Soldier Effectiveness Directorate, United States Army Combat Capabilities Development Command Soldier Center, Natick, MA, United States., Margolis LM; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, United States. Electronic address: lee.m.margolis.civ@health.mil.
Jazyk: angličtina
Zdroj: The Journal of nutrition [J Nutr] 2023 Jun; Vol. 153 (6), pp. 1696-1709. Date of Electronic Publication: 2023 Mar 08.
DOI: 10.1016/j.tjnut.2023.03.002
Abstrakt: Background: Increasing β-hydroxybutyrate (βHB) availability through ketone monoester (KE) plus carbohydrate supplementation is suggested to enhance physical performance by sparing glucose use during exercise. However, no studies have examined the effect of ketone supplementation on glucose kinetics during exercise.
Objectives: This exploratory study primarily aimed to determine the effect of KE plus carbohydrate supplementation on glucose oxidation during steady-state exercise and physical performance compared with carbohydrate alone.
Methods: Using a randomly assigned, crossover design, 12 men consumed 573 mg KE/kg body mass plus 110 g glucose (KE+CHO) or 110 g glucose (CHO) before and during 90 min of steady-state treadmill exercise [54 ± 3% peak oxygen uptake (V˙O 2peak )] wearing a weighted vest (30% body mass; 25 ± 3 kg). Glucose oxidation and turnover were determined using indirect calorimetry and stable isotopes. Participants performed an unweighted time to exhaustion (TTE; 85% V˙O 2peak ) after steady-state exercise and a weighted (25 ± 3 kg) 6.4 km time trial (TT) the next day after consuming a bolus of KE+CHO or CHO. Data were analyzed by paired t-tests and mixed model ANOVA.
Results: βHB concentrations were higher (P < 0.05) after exercise [2.1 mM (95% CI: 1.6, .6)] and the TT [2.6 mM (2.1, 3.1)] in KE+CHO compared with CHO. TTE was lower [-104 s (-201, -8)], and TT performance was slower [141 s (19,262)] in KE+CHO than in CHO (P < 0.05). Exogenous [-0.01 g/min (-0.07, 0.04)] and plasma [-0.02 g/min (-0.08, 0.04)] glucose oxidation and metabolic clearance rate {MCR [0.38 mg·kg -1 ·min -1 (-0.79, 1.54)]} were not different, and glucose rate of appearance [-0.51 mg·kg -1 ·min -1 (-0.97, -0.04)], and disappearance [-0.50 mg·kg -1 ·min -1 (-0.96, -0.04)] were lower (P < 0.05) in KE+CHO compared with CHO during steady-state exercise.
Conclusions: In the current study, rates of exogenous and plasma glucose oxidation and MCR were not different between treatments during steady-state exercise, suggesting blood glucose utilization is similar between KE+CHO and CHO. KE+CHO supplementation also results in lower physical performance compared with CHO alone. This trial was registered at www.
Clinicaltrials: gov as NCT04737694.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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