Antibody response over time correlated with treatment outcome in 30 dogs naturally infected with Brucella canis (2017-2022).
| Autor: | Guarino C, Franklin-Guild R, Goodrich E, Conklin R, Frye E, Pinn-Woodcock T |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | American journal of veterinary research [Am J Vet Res] 2023 Mar 13; Vol. 84 (4). Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023). |
| DOI: | 10.2460/ajvr.23.01.0014 |
| Abstrakt: | Objective: Brucella canis is a zoonotic bacterial pathogen of dogs that is notoriously difficult to diagnose and treat. Humans can become infected with B canis when an infected pet dog is brought into their home. Our objectives were to describe the clinical presentation and outcomes in dogs treated for B canis and evaluate the performance of the quantitative serologic canine Brucella multiplex (CBM) assay for monitoring treatment response. Animals: Diagnostic records from the Animal Health Diagnostic Center at Cornell University were retrospectively reviewed (2017-2022) for dogs that underwent repeat B canis serologic testing. Medical records were requested to compare the clinical presentations and outcomes for dogs that underwent treatment for B canis. Changes in CBM antibody values were compared between dogs with and without resolution of clinical signs. Results: While treatment protocols varied in the 30 treated dogs meeting the inclusion criteria, poly-antimicrobial therapy was prescribed in 97% (29/30) of cases. Gait abnormalities, spinal pain, and discospondylitis were the most common clinical abnormalities. A difference (P value = .0075) in the percent decrease in CBM assay PO1 antibody values was found in dogs with resolved clinical signs. Clinical Relevance: Young dogs presenting with recurring lameness or back pain should be screened for B canis infection. A 40% decline in CBM assay values 2 to 6 months posttreatment can be supportive of response to treatment. Further prospective studies are needed to determine the ideal B canis treatment regimen and the magnitude of public health risks associated with maintaining neutered B canis-infected animals as pets. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|