Five-year follow-up mortality prognostic index for colorectal patients.

Autor: Orive M; Department of Social Psychology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria, Spain. Miren.orive@ehu.eus.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain. Miren.orive@ehu.eus.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain. Miren.orive@ehu.eus., Barrio I; Department of Mathematics, University of the Basque Country UPV/EHU, Leioa, Spain.; Basque Center for Applied Mathematics, BCAM, Bilbao, Spain., Lázaro S; Servicio de Cirugía General, Hospital Basurto, Bilbao, Bizkaia, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain., Gonzalez N; Unidad de Investigación, Hospital Galdakao-Usansolo, Galdakao, Bizkaia, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain.; Kronikgune Institute for Health Services Research, Barakaldo, Spain., Bare M; Unidad de Epidemiología Clínica, Corporacio Parc Tauli, Barcelona, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain., de Larrea NF; Centro Nacional de Epidemiología, ISCIII, Madrid, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Redondo M; Unidad de Investigación, Hospital Costa del Sol, Malaga, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain., Cortajarena S; Department of Mathematics, University of the Basque Country UPV/EHU, Leioa, Spain., Bilbao A; Unidad de Investigación, Hospital Basurto, Bilbao, Bizkaia, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain., Aguirre U; Unidad de Investigación, Hospital Galdakao-Usansolo, Galdakao, Bizkaia, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain., Sarasqueta C; Unidad de Investigación, Hospital Donostia/BioDonostia, Donostia, Gipuzkoa, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain., Quintana JM; Unidad de Investigación, Hospital Galdakao-Usansolo, Galdakao, Bizkaia, Spain.; Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao, Spain.; Red de Investigación en Cronicidad, Atención Primaria y Promoción de La Salud (RICAPPS), Galdakao, Spain.
Jazyk: angličtina
Zdroj: International journal of colorectal disease [Int J Colorectal Dis] 2023 Mar 09; Vol. 38 (1), pp. 64. Date of Electronic Publication: 2023 Mar 09.
DOI: 10.1007/s00384-023-04358-0
Abstrakt: Purpose: To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient's health-related quality of life (HRQoL) status.
Methods: Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used.
Results: We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively.
Conclusions: These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables.
Implications for Cancer Survivors: Patients with colorectal cancer should be monitored more closely depending on the severity of their disease and comorbidities as well as the perceived health-related quality of life, and preventive measures should be established to prevent adverse outcomes and therefore to ensure that better treatment is received.
Trial Registration: ClinicalTrials.gov identifier: NCT02488161.
(© 2023. The Author(s).)
Databáze: MEDLINE
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