The combination of oral and topical photoprotection with a standardized Polypodium leucotomos extract is beneficial against actinic keratosis.

Autor: Pellacani G; Dermatology Clinic, University La Sapienza, Rome, Italy., Peris K; Dermatology Clinic, Catholic University, Rome, Italy., Ciardo S; Dermatology Clinic, University of Modena and Reggio Emilia, Modena, Italy., Pezzini C; Dermatology Clinic, University of Modena and Reggio Emilia, Modena, Italy., Tambone S; Dermatology Clinic, Catholic University, Rome, Italy., Farnetani F; Dermatology Clinic, University of Modena and Reggio Emilia, Modena, Italy., Longo C; Ospedale S. Maria Nuova - IRCCS, Reggio Emilia, Italy., Chello C; Dermatology Clinic, University La Sapienza, Rome, Italy., González S; Department of Medicine and Medical Specialties, Alcalá de Henares University, Madrid, Spain.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2023 Jul; Vol. 39 (4), pp. 384-391. Date of Electronic Publication: 2023 Mar 31.
DOI: 10.1111/phpp.12870
Abstrakt: Introduction: This study describes a prospective, multicentre, randomized controlled, open-label study with three arms aimed at studying the differences between: [Cnt], self-administered sun protection; [T], topical treatment; and [TO], topical + oral treatment; for the management of Actinic Keratosis (AK) in a cohort of subjects of advanced age displaying severe actinic damage (SAD).
Methods: Treatments administered to groups [T] and [TO] had a common component, which is a botanical extract, Fernblock, with demonstrated photoprotective activity.
Results: In total, 131 subjects were distributed randomly in the three groups, and followed up clinically at three separate time points, beginning of the study (t = 0) and after 6 and 12 months. Analysis of clinical data and examination using reflectance confocal microscopy (RCM) revealed that group [T] and [TO] displayed decreased clinical AK and field cancerization parameters, including the number of new lesions, and reduced the need for additional interventions in these patients. RCM revealed normalization of the keratinocyte layer. Improvements in AK and field cancerization parameters were greatest in the group [TO], suggesting that topical and oral photoprotection improves the clinical and anatomical outcome compared to control conditions.
Conclusions: The combination of topical and oral immune photoprotection provides an advantage compared to topical photoprotection alone.
(© 2023 The Authors. Photodermatology, Photoimmunology & Photomedicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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