Polycaprolactone-MXene Nanofibrous Scaffolds for Tissue Engineering.

Autor: Diedkova K; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; University of Latvia, 3 Jelgavas Street, Riga LV-1004, Latvia., Pogrebnjak AD; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; Department of Motor Vehicles, Lublin University of Technology, Nadbystrzycka 38 A, Lublin 20-618, Poland.; Al-Farabi Kazakh National University, 71 Al-Farabi Avenue, Almaty 050040, Kazakhstan., Kyrylenko S; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine., Smyrnova K; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, J. Bottu 25, Trnava 917 24, Slovakia., Buranich VV; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine., Horodek P; Henryk Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Street, Krakow 31-342, Poland., Zukowski P; Department of Electrical Devices and High Voltage Technology, Lublin University of Technology, 38 D Nadbystrzycka Street, Lublin 20-618, Poland., Koltunowicz TN; Department of Electrical Devices and High Voltage Technology, Lublin University of Technology, 38 D Nadbystrzycka Street, Lublin 20-618, Poland., Galaszkiewicz P; Department of Electrical Devices and High Voltage Technology, Lublin University of Technology, 38 D Nadbystrzycka Street, Lublin 20-618, Poland., Makashina K; East-Kazakhstan State Technical University, D. Serikbayev Street, 19, Ust-Kamenogorsk 070000, Kazakhstan., Bondariev V; Department of Electrical Devices and High Voltage Technology, Lublin University of Technology, 38 D Nadbystrzycka Street, Lublin 20-618, Poland., Sahul M; Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, J. Bottu 25, Trnava 917 24, Slovakia., Čaplovičová M; Centre for Nanodiagnostics of Materials, Slovak University of Technology in Bratislava, 5 Vazovova Street, Bratislava 812 43, Slovakia., Husak Y; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; Faculty of Chemistry, Silesian University of Technology, 9 Strzody Street, Gliwice 44-100, Poland., Simka W; Faculty of Chemistry, Silesian University of Technology, 9 Strzody Street, Gliwice 44-100, Poland., Korniienko V; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; University of Latvia, 3 Jelgavas Street, Riga LV-1004, Latvia., Stolarczyk A; Faculty of Chemistry, Silesian University of Technology, 9 Strzody Street, Gliwice 44-100, Poland., Blacha-Grzechnik A; Faculty of Chemistry, Silesian University of Technology, 9 Strzody Street, Gliwice 44-100, Poland., Balitskyi V; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine., Zahorodna V; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine., Baginskiy I; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine., Riekstina U; University of Latvia, 3 Jelgavas Street, Riga LV-1004, Latvia., Gogotsi O; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03142, Ukraine., Gogotsi Y; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; A. J. Drexel Nanomaterials Institute, and Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States., Pogorielov M; Sumy State University, 2 Rymskogo-Korsakova Street, Sumy 40007, Ukraine.; University of Latvia, 3 Jelgavas Street, Riga LV-1004, Latvia.
Jazyk: angličtina
Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Mar 09. Date of Electronic Publication: 2023 Mar 09.
DOI: 10.1021/acsami.2c22780
Abstrakt: New conductive materials for tissue engineering are needed for the development of regenerative strategies for nervous, muscular, and heart tissues. Polycaprolactone (PCL) is used to obtain biocompatible and biodegradable nanofiber scaffolds by electrospinning. MXenes, a large class of biocompatible 2D nanomaterials, can make polymer scaffolds conductive and hydrophilic. However, an understanding of how their physical properties affect potential biomedical applications is still lacking. We immobilized Ti 3 C 2 T x MXene in several layers on the electrospun PCL membranes and used positron annihilation analysis combined with other techniques to elucidate the defect structure and porosity of nanofiber scaffolds. The polymer base was characterized by the presence of nanopores. The MXene surface layers had abundant vacancies at temperatures of 305-355 K, and a voltage resonance at 8 × 10 4 Hz with the relaxation time of 6.5 × 10 6 s was found in the 20-355 K temperature interval. The appearance of a long-lived component of the positron lifetime was observed, which was dependent on the annealing temperature. The study of conductivity of the composite scaffolds in a wide temperature range, including its inductive and capacity components, showed the possibility of the use of MXene-coated PCL membranes as conductive biomaterials. The electronic structure of MXene and the defects formed in its layers were correlated with the biological properties of the scaffolds in vitro and in bacterial adhesion tests. Double and triple MXene coatings formed an appropriate environment for cell attachment and proliferation with mild antibacterial effects. A combination of structural, chemical, electrical, and biological properties of the PCL-MXene composite demonstrated its advantage over the existing conductive scaffolds for tissue engineering.
Databáze: MEDLINE