In vitro modeling of the neurobiological effects of glucocorticoids: A review.

Autor:	Bassil K; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Krontira AC; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Munich, Germany., Leroy T; Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium., Escoto AIH; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Snijders C; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Pernia CD; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center (UMC) Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands., de Nijs L; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., van den Hove D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Kenis G; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Boks MP; Psychiatry, UMC Utrecht Brain Center, Utrecht, the Netherlands., Vadodaria K; Salk Institute for Biological Studies, La Jolla, San Diego, United States., Daskalakis NP; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; International Max Planck Research School for Translational Psychiatry, Munich, Germany., Rutten BPF; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Jazyk:	angličtina
Zdroj:	Neurobiology of stress [Neurobiol Stress] 2023 Feb 23; Vol. 23, pp. 100530. Date of Electronic Publication: 2023 Feb 23 (Print Publication: 2023).
DOI:	10.1016/j.ynstr.2023.100530
Abstrakt:	Hypothalamic-pituitary adrenal (HPA)axis dysregulation has long been implicated in stress-related disorders such as major depression and post-traumatic stress disorder. Glucocorticoids (GCs) are released from the adrenal glands as a result of HPA-axis activation. The release of GCs is implicated with several neurobiological changes that are associated with negative consequences of chronic stress and the onset and course of psychiatric disorders. Investigating the underlying neurobiological effects of GCs may help to better understand the pathophysiology of stress-related psychiatric disorders. GCs impact a plethora of neuronal processes at the genetic, epigenetic, cellular, and molecular levels. Given the scarcity and difficulty in accessing human brain samples, 2D and 3D in vitro neuronal cultures are becoming increasingly useful in studying GC effects. In this review, we provide an overview of in vitro studies investigating the effects of GCs on key neuronal processes such as proliferation and survival of progenitor cells, neurogenesis, synaptic plasticity, neuronal activity, inflammation, genetic vulnerability, and epigenetic alterations. Finally, we discuss the challenges in the field and offer suggestions for improving the use of in vitro models to investigate GC effects. Competing Interests: The authors have no conflicts of interest to declare that are relevant to the content of this article. (© 2023 The Authors.)
Databáze:	MEDLINE
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