Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

Autor: Ohene-Nyako M; Pharmacology and Toxicology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA., Nass SR; Pharmacology and Toxicology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA., Richard HT; Pathology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA., Lukande R; Pathology, College of Health Sciences, 58589Makerere University, Kampala, Uganda., Nicol MR; Experimental and Clinical Pharmacology, College of Pharmacy, 15515University of Minnesota, Minneapolis, MN, USA., McRae M; Pharmacotherapy and Outcomes Science, School of Pharmacy, 15535Virginia Commonwealth University, Richmond, VA, USA., Knapp PE; Pharmacology and Toxicology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.; Anatomy and Neurobiology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.; Institute for Drug and Alcohol Studies, 6886Virginia Commonwealth University, Richmond, VA, USA., Hauser KF; Pharmacology and Toxicology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.; Anatomy and Neurobiology, School of Medicine, 6886Virginia Commonwealth University, Richmond, VA, USA.; Institute for Drug and Alcohol Studies, 6886Virginia Commonwealth University, Richmond, VA, USA.
Jazyk: angličtina
Zdroj: ASN neuro [ASN Neuro] 2023 Jan-Dec; Vol. 15, pp. 17590914231158218.
DOI: 10.1177/17590914231158218
Abstrakt: Summary Statement: HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity and protein levels.
Databáze: MEDLINE