Mouse and rat ultrasonic vocalizations in neuroscience and neuropharmacology: State of the art and future applications.

Autor: Premoli M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Pietropaolo S; University of Bordeaux, CNRS, INCIA, UMR 5287, Bordeaux, France., Wöhr M; Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, KU Leuven, Leuven, Belgium.; Leuven Brain Institute, KU Leuven, Leuven, Belgium.; Faculty of Psychology, Experimental and Biological Psychology, Behavioral Neuroscience, Philipps-University of Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior, Marburg, Germany., Simola N; Department of Biomedical Sciences, University of Cagliari, Monserrato University Campus, Monserrato, Italy., Bonini SA; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2023 Jun; Vol. 57 (12), pp. 2062-2096. Date of Electronic Publication: 2023 Mar 26.
DOI: 10.1111/ejn.15957
Abstrakt: Mice and rats emit ultrasonic vocalizations (USVs), which may express their arousal and emotional states, to communicate with each other. There is continued scientific effort to better understand the functions of USVs as a central element of the rodent behavioral repertoire. However, studying USVs is not only important because of their ethological relevance, but also because they are widely applied as a behavioral readout in various fields of biomedical research. In mice and rats, a large number of experimental models of brain disorders exist and studying the emission of USVs in these models can provide valuable information about the health status of the animals and the effectiveness of possible interventions, both environmental and pharmacological. This review (i) provides an updated overview of the contexts in which ultrasonic calling behaviour of mice and rats has particularly high translational value, and (ii) gives some examples of novel approaches and tools used for the analysis of USVs in mice and rats, combining qualitative and quantitative methods. The relevance of age and sex differences as well as the importance of longitudinal evaluations of calling and non-calling behaviour is also discussed. Finally, the importance of assessing the communicative impact of USVs in the receiver, that is, through playback studies, is highlighted.
(© 2023 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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