Highly pathogenic avian influenza A (H5N1) virus infections in wild carnivores connected to mass mortalities of pheasants in Finland.

Autor: Tammiranta N; Finnish Food Authority, Animal Health Diagnostic Unit, Veterinary Virology, Mustialankatu 3, FI-00790 Helsinki, Finland. Electronic address: niina.tammiranta@ruokavirasto.fi., Isomursu M; Finnish Food Authority, Animal Health Diagnostic Unit, Wild Animal Pathology, Elektroniikkatie 3, FI-90590 Oulu, Finland., Fusaro A; Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro, PD, Italy., Nylund M; Finnish Food Authority, Animal Health Diagnostic Unit, Wild Animal Pathology, Elektroniikkatie 3, FI-90590 Oulu, Finland., Nokireki T; Finnish Food Authority, Animal Health Diagnostic Unit, Veterinary Virology, Mustialankatu 3, FI-00790 Helsinki, Finland., Giussani E; Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro, PD, Italy., Zecchin B; Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro, PD, Italy., Terregino C; Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro, PD, Italy., Gadd T; Finnish Food Authority, Animal Health Diagnostic Unit, Veterinary Virology, Mustialankatu 3, FI-00790 Helsinki, Finland.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2023 Jul; Vol. 111, pp. 105423. Date of Electronic Publication: 2023 Mar 06.
DOI: 10.1016/j.meegid.2023.105423
Abstrakt: Highly pathogenic avian influenza (HPAI) has caused widespread mortality in both wild and domestic birds in Europe during 2020-2022. Virus types H5N8 and H5N1 have dominated the epidemic. Isolated spill-over infections in mammals started to emerge as the epidemic continued. In autumn 2021, HPAI H5N1 caused a series of mass mortality events in farmed and released pheasants (Phasianus colchicus) in a restricted area in southern Finland. Later, in the same area, an otter (Lutra lutra), two red foxes (Vulpes vulpes) and a lynx (Lynx lynx) were found moribund or dead and infected with H5N1 HPAI virus. Phylogenetically, H5N1 strains from pheasants and mammals clustered together. Molecular analyses of the four mammalian virus strains revealed mutations in the PB2 gene segment (PB2-E627K and PB2-D701N) that are known to facilitate viral replication in mammals. This study revealed that avian influenza cases in mammals were spatially and temporally connected with avian mass mortalities suggesting increased infection pressure from birds to mammals.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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