Communication dynamics in the human connectome shape the cortex-wide propagation of direct electrical stimulation.

Autor:	Seguin C; Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA. Electronic address: caio.seguin@unimelb.edu.au., Jedynak M; Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France., David O; Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France., Mansour S; Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia; Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia., Sporns O; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Cognitive Science Program, Indiana University, Bloomington, IN, USA; Program in Neuroscience, Indiana University, Bloomington, IN, USA; Network Science Institute, Indiana University, Bloomington, IN, USA., Zalesky A; Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia; Department of Biomedical Engineering, Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2023 May 03; Vol. 111 (9), pp. 1391-1401.e5. Date of Electronic Publication: 2023 Mar 07.
DOI:	10.1016/j.neuron.2023.01.027
Abstrakt:	Communication between gray matter regions underpins all facets of brain function. We study inter-areal communication in the human brain using intracranial EEG recordings, acquired following 29,055 single-pulse direct electrical stimulations in a total of 550 individuals across 20 medical centers (average of 87 ± 37 electrode contacts per subject). We found that network communication models-computed on structural connectivity inferred from diffusion MRI-can explain the causal propagation of focal stimuli, measured at millisecond timescales. Building on this finding, we show that a parsimonious statistical model comprising structural, functional, and spatial factors can accurately and robustly predict cortex-wide effects of brain stimulation (R 2 =46% in data from held-out medical centers). Our work contributes toward the biological validation of concepts in network neuroscience and provides insight into how connectome topology shapes polysynaptic inter-areal signaling. We anticipate that our findings will have implications for research on neural communication and the design of brain stimulation paradigms. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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