EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases.

Autor:	Pop RM; 1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania.; 2Department of Internal Medicine, Carol Davila University of Medicine, Bucharest, District 5, 8 Eroii Sanitari, 050474, Romania., Diaconu CI; 1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania., Rimbaş M; 1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania.; 2Department of Internal Medicine, Carol Davila University of Medicine, Bucharest, District 5, 8 Eroii Sanitari, 050474, Romania., Mateescu RB; 1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania.; 2Department of Internal Medicine, Carol Davila University of Medicine, Bucharest, District 5, 8 Eroii Sanitari, 050474, Romania., Rouhani F; 1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania., Popp C; 3Department of Pathology, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare, 020125, Romania., Manfrin E; 4Department of Diagnostics and Public Health, Section of Pathology, University of Verona, 10 Piazzale Ludovico Antonio Scuro, 37124, Verona, Italy., Crinò SF; 5Digestive Endoscopy Unit, The Pancreas Institute, G.B. Rossi University Hospital, 10 Piazzale LA Scuro, 37126, Verona, Italy., Cauni V; 6Urology Department, Colentina Clinical Hospital, Bucharest, District 2, 19-21 Stefan cel Mare street, 020125, Romania.
Jazyk:	angličtina
Zdroj:	Romanian journal of internal medicine = Revue roumaine de medecine interne [Rom J Intern Med] 2023 May 08; Vol. 61 (2), pp. 116-124. Date of Electronic Publication: 2023 May 08 (Print Publication: 2023).
DOI:	10.2478/rjim-2023-0008
Abstrakt:	Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis. (© 2023 Ruxandra Mihaela Pop et al., published by Sciendo.)
Databáze:	MEDLINE
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