Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment.

Autor:	Garmendia I; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Varthaman A; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Marmier S; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Angrini M; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Matchoua I; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Darbois-Delahousse A; INSERM U932, PSL Universite, Institut Curie, Paris, France., Josseaume N; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Foy PE; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Roumenina LT; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Naouar N; ARTbio Platform, Institut de Biologie Paris Seine, Institut Français de Bioinformatique, Sorbonne-Universite, Paris, France., Meylan M; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Sibéril S; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Russick J; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Joubert PE; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France., Leroy K; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.; Department of Biochemistry, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris Centre, Universite Paris Cite, Paris, France., Damotte D; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.; Departments of Pathology and Thoracic Surgery, Hopital Cochin, Assistance Publique Hopitaux de Paris Centre, Universite Paris Cite, Paris, France., Mansuet-Lupo A; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.; Departments of Pathology and Thoracic Surgery, Hopital Cochin, Assistance Publique Hopitaux de Paris Centre, Universite Paris Cite, Paris, France., Wislez M; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.; Department of Respiratory Medicine and Thoracic Oncology, Hopital Cochin, Assistance Publique Hopitaux de Paris Centre, Universite Paris Cite, Paris, France., Alifano M; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.; Department of Thoracic Surgery, Hopital Cochin, Assistance Publique Hopitaux de Paris Centre, Universite Paris Cite, Paris, France., Menger L; INSERM U932, PSL Universite, Institut Curie, Paris, France., Garcia-Verdugo I; INSERM U1152, Laboratoire d'Excellence Inflamex, Universite de Paris, Hopital Bichat - Claude-Bernard, Paris, France., Sallenave JM; INSERM U1152, Laboratoire d'Excellence Inflamex, Universite de Paris, Hopital Bichat - Claude-Bernard, Paris, France., Lantz O; INSERM U932, PSL Universite, Institut Curie, Paris, France.; Laboratoire d'Immunologie Clinique, Institut Curie, Paris, France.; Centre d'Investigation Clinique en Biotherapie, Institut Curie (CIC-BT1428), Paris, France., Petitprez F; Programme Cartes d'Ldentite des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France.; MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom., Cremer I; Team Inflammation, Complement and Cancer, Centre de Recherche des Cordeliers, Sorbonne Universite, INSERM, Universite Paris Cite, Paris, France.
Jazyk:	angličtina
Zdroj:	Cancer immunology research [Cancer Immunol Res] 2023 Apr 03; Vol. 11 (4), pp. 530-545.
DOI:	10.1158/2326-6066.CIR-22-0534
Abstrakt:	One billion people worldwide get flu every year, including patients with non-small cell lung cancer (NSCLC). However, the impact of acute influenza A virus (IAV) infection on the composition of the tumor microenvironment (TME) and the clinical outcome of patients with NSCLC is largely unknown. We set out to understand how IAV load impacts cancer growth and modifies cellular and molecular players in the TME. Herein, we report that IAV can infect both tumor and immune cells, resulting in a long-term protumoral effect in tumor-bearing mice. Mechanistically, IAV impaired tumor-specific T-cell responses, led to the exhaustion of memory CD8+ T cells and induced PD-L1 expression on tumor cells. IAV infection modulated the transcriptomic profile of the TME, fine-tuning it toward immunosuppression, carcinogenesis, and lipid and drug metabolism. Consistent with these data, the transcriptional module induced by IAV infection in tumor cells in tumor-bearing mice was also found in human patients with lung adenocarcinoma and correlated with poor overall survival. In conclusion, we found that IAV infection worsened lung tumor progression by reprogramming the TME toward a more aggressive state. (©2023 American Association for Cancer Research.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu