Copper-catalyzed C2-selective alkynylation of chromones via 1,4-conjugate addition.

Autor: Li YW; School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, China.; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Lei J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, 402160, China. jlei0916@163.com., Chen ZZ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, 402160, China. 18883138277@163.com., Lv ML; School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, China. mllv@gzu.edu.cn.
Jazyk: angličtina
Zdroj: Molecular diversity [Mol Divers] 2024 Feb; Vol. 28 (1), pp. 125-131. Date of Electronic Publication: 2023 Mar 07.
DOI: 10.1007/s11030-023-10625-7
Abstrakt: Copper-catalyzed selective alkynylation with N-propargyl carboxamides as nucleophiles has been successfully developed for the synthesis of C2-functionalized chromanones. Under optimized reaction conditions, 21 examples were obtained in one-pot procedure through 1,4-conjugate addition. This protocol features readily available feedstocks, easy operations, and moderate to good yields, which provides viable access to pharmacologically active C2-functionalized chromanones.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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