The clinical features, management and outcomes of lymphoma in pregnancy: A multicentre study by the Australasian Lymphoma Alliance.

Autor: Di Ciaccio PR; Sydney Adventist Hospital, Wahroonga, New South Wales, Australia.; College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Mills G; Northern Beaches Hospital, Frenchs Forest, New South Wales, Australia.; Faculty of Medicine, Macquarie University, Ryde, New South Wales, Australia., Shipton MJ; Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Campbell B; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia., Gregory G; Monash Health, Clayton, Victoria, Australia., Langfield J; Royal North Shore Hospital, St Leonards, New South Wales, Australia., Greenwood M; Royal North Shore Hospital, St Leonards, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia., McKeague S; Mater Hospital Brisbane, Brisbane, Queensland, Australia., Shanavas M; Mater Hospital Brisbane, Brisbane, Queensland, Australia.; University of Queensland, Brisbane, Queensland, Australia., Eslick R; The Canberra Hospital, Garran, Australian Capital Territory, Australia., Kidson-Gerber G; Prince of Wales Hospital and The Royal Hospital for Women, Randwick, New South Wales, Australia.; Faculty of Medicine and Health, University of New South Wales, Randwick, New South Wales, Australia., Smallbone P; Fiona Stanley Hospital, Perth, Western Australia, Australia., Tang C; Gosford Hospital, Gosford, New South Wales, Australia.; School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia., Morris K; Royal Brisbane and Women's Hospital, Herston, Queensland, Australia., Bilmon I; Sydney Adventist Hospital, Wahroonga, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.; Westmead Hospital, Westmead, New South Wales, Australia., Yannakou CK; Epworth Freemasons, Epworth HealthCare, Melbourne, Victoria, Australia., Badoux X; St George Hospital, Kogarah, New South Wales, Australia., Berkahn L; Auckland Hospital, Auckland, New Zealand., Farina S; Royal Hobart Hospital, Hobart, Tasmania, Australia., Mason KD; Royal Melbourne Hospital, Melbourne, Victoria, Australia.; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Motum P; Liverpool Hospital, Liverpool, New South Wales, Australia., Goss K; Monash Health, Clayton, Victoria, Australia., Hamad N; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; Department of Haematology, St Vincent's Hospital, Sydney, New South Wales, Australia.; School of Medicine, Sydney, University of Notre, Sydney, New South Wales, Australia.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2023 Jun; Vol. 201 (5), pp. 887-896. Date of Electronic Publication: 2023 Mar 07.
DOI: 10.1111/bjh.18727
Abstrakt: Lymphoma in pregnancy (LIP) presents unique clinical, social and ethical challenges; however, the evidence regarding this clinical scenario is limited. We conducted a multicentre retrospective observational study reporting on the features, management, and outcomes of LIP in patients diagnosed between January 2009 and December 2020 at 16 sites in Australia and New Zealand for the first time. We included diagnoses occurring either during pregnancy or within the first 12 months following delivery. A total of 73 patients were included, 41 diagnosed antenatally (AN cohort) and 32 postnatally (PN cohort). The most common diagnoses were Hodgkin lymphoma (HL; 40 patients), diffuse large B-cell lymphoma (DLBCL; 11) and primary mediastinal B-cell lymphoma (PMBCL; six). At a median follow up of 2.37 years, the 2- and 5-year overall survival (OS) for patients with HL were 91% and 82%. For the combined DLBCL and PMBCL group, the 2-year OS was 92%. Standard curative chemotherapy regimens were successfully delivered to 64% of women in the AN cohort; however, counselling regarding future fertility and termination of pregnancy were suboptimal, and a standardised approach to staging lacking. Neonatal outcomes were generally favourable. We present a large multicentre cohort of LIP reflecting contemporary practice and identify areas in need of ongoing research.
(© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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