Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs.

Autor: do Vale TL; Postgraduate Program in Health Sciences, Federal University of Maranhão (UFMA), São Luís, MA, Brazil., Costa AR; Department of Pathology, State University of Maranhão (UEMA), São Luís, MA, Brazil., Miranda LM; Department of Pathology, State University of Maranhão (UEMA), São Luís, MA, Brazil., Silva GF; Department of Pathology, Federal University of Maranhão (UFMA), São Luís, MA, Brazil., Silva NCS; Postgraduate Program in Health Sciences, Federal University of Maranhão (UFMA), São Luís, MA, Brazil., Lima TB; Department of Pathology, State University of Maranhão (UEMA), São Luís, MA, Brazil., Chaves DP; Department of Pathology, State University of Maranhão (UEMA), São Luís, MA, Brazil., Sager H; Elanco Animal Health Inc, Basel, Switzerland., Lasmar PVF; Elanco Animal Health Inc, São Paulo, Brazil., Costa-Junior LM; Postgraduate Program in Health Sciences, Federal University of Maranhão (UFMA), São Luís, MA, Brazil. livio.martins@ufma.br.
Jazyk: angličtina
Zdroj: Parasites & vectors [Parasit Vectors] 2023 Mar 06; Vol. 16 (1), pp. 86. Date of Electronic Publication: 2023 Mar 06.
DOI: 10.1186/s13071-023-05661-z
Abstrakt: Background: The New World screwworm fly, Cochliomyia hominivorax, is widely distributed across South America. This parasitic insect is a significant cause of primary myiasis in animals, including dogs. There is an urgent need for a rapid and efficient treatment to improve the recovery of affected animals. In the present study we evaluated the potential of lotilaner for the treatment of myiasis caused by C. hominivorax larvae in naturally infested dogs. Lotilaner belongs to the isoxazoline class of chemical compounds and is marketed as Credelio™ for use against ticks and fleas in dogs and cats.
Methods: Eleven dogs with naturally acquired myiasis were enrolled in this study based on the severity of lesions and the number of identified larvae. All animals received a single oral administration of lotilaner at a minimum dose of 20.5 mg/kg body weight. After treatment, the number of expelled larvae, live or dead, was determined at 2, 6 and 24 h, and the larval expulsion rate, larvicidal effect and overall efficacy were calculated. After 24 h, the remaining larvae were removed, counted and identified. The lesions were cleaned, and palliative treatment was administered when necessary, according to the animal's health status.
Results: All larvae were identified as C. hominivorax. The larval expulsion rate was 80.5% and 93.0% at 2 and 6 h post-treatment, respectively. Lotilaner showed an overall efficacy of 100% at 24 h post-treatment.
Conclusions: Lotilaner demonstrated a rapid onset of action and a high efficacy against C. hominivorax. We therefore recommend lotilaner for the effective treatment of myiasis in dogs.
(© 2023. The Author(s).)
Databáze: MEDLINE
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