A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1.

Autor: Geiller T; Department of Neuroscience, Columbia University, New York, NY, 10027, USA; Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, 10027, USA. Electronic address: https://twitter.com/tgeiller., Priestley JB; Department of Neuroscience, Columbia University, New York, NY, 10027, USA; Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, 10027, USA; Center for Theoretical Neuroscience, Columbia University, New York, NY, 10027, USA. Electronic address: https://twitter.com/jamespriestley4., Losonczy A; Department of Neuroscience, Columbia University, New York, NY, 10027, USA; Mortimer B Zuckerman Mind Brain Behavior Institute, New York, NY, 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY, 10027, USA. Electronic address: al2856@columbia.edu.
Jazyk: angličtina
Zdroj: Current opinion in neurobiology [Curr Opin Neurobiol] 2023 Apr; Vol. 79, pp. 102701. Date of Electronic Publication: 2023 Mar 04.
DOI: 10.1016/j.conb.2023.102701
Abstrakt: The hippocampus is a multi-stage neural circuit that is critical for memory formation. Its distinct anatomy has long inspired theories that rely on local interactions between neurons within each subregion in order to perform serial operations important for memory encoding and storage. These local computations have received less attention in CA1 area, the primary output node of the hippocampus, where excitatory neurons are thought to be only very sparsely interconnected. However, recent findings have demonstrated the power of local circuitry in CA1, with evidence for strong functional interactions among excitatory neurons, regulation by diverse inhibitory microcircuits, and novel plasticity rules that can profoundly reshape the hippocampal ensemble code. Here we review how these properties expand the dynamical repertoire of CA1 beyond the confines of feedforward processing, and what implications they have for hippocampo-cortical functions in memory formation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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