Multimodal exploration of the intracranial aneurysm wall.

Autor: Niemann A; Department of Simulation and Graphics, Otto-von-Guericke University, Magdeburg, Germany.; STIMULATE Research Campus, Magdeburg, Germany., Tulamo R; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Netti E; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Preim B; Department of Simulation and Graphics, Otto-von-Guericke University, Magdeburg, Germany.; STIMULATE Research Campus, Magdeburg, Germany., Berg P; STIMULATE Research Campus, Magdeburg, Germany.; Department of Medical Engineering, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Cebral J; Computational Hemodynamics Lab, Georg Mason University, Fairfax, USA., Robertson A; Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, USA., Saalfeld S; Department of Simulation and Graphics, Otto-von-Guericke University, Magdeburg, Germany. sylvia.saalfeld@ovgu.de.; STIMULATE Research Campus, Magdeburg, Germany. sylvia.saalfeld@ovgu.de.
Jazyk: angličtina
Zdroj: International journal of computer assisted radiology and surgery [Int J Comput Assist Radiol Surg] 2023 Dec; Vol. 18 (12), pp. 2243-2252. Date of Electronic Publication: 2023 Mar 06.
DOI: 10.1007/s11548-023-02850-0
Abstrakt: Purpose: Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restricted to ex vivo 2D slices where the shape of the tissue is altered.
Methods: We developed a visual exploration pipeline for a comprehensive view of an IA. We extract multimodal information (like stain classification and segmentation of histologic images) and combine them via 2D to 3D mapping and virtual inflation of deformed tissue. Histological data, including four stains, micro-CT data and segmented calcifications as well as hemodynamic information like wall shear stress (WSS), are combined with the 3D model of the resected aneurysm.
Results: Calcifications were mostly present in the tissue part with increased WSS. In the 3D model, an area of increased wall thickness was identified and correlated to histology, where the Oil red O (ORO) stained images showed a lipid accumulation and the alpha-smooth muscle actin (aSMA) stained images showed a slight loss of muscle cells.
Conclusion: Our visual exploration pipeline combines multimodal information about the aneurysm wall to improve the understanding of wall changes and IA development. The user can identify regions and correlate how hemodynamic forces, e.g. WSS, are reflected by histological structures of the vessel wall, wall thickness and calcifications.
(© 2023. The Author(s).)
Databáze: MEDLINE
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