Theobroma cacao fortified-feed ameliorates potassium bromate-induced oxidative damage in male Wistar rat.

Autor:	Nwonuma CO; Department of Biochemistry, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria.; Landmark University SDG 3 (Good Health and Wellbeing Research Group), Omu-Aran, Kwara State, Nigeria., Abdurrahman JE; Department of Biochemistry, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria., Rotimi DE; Department of Biochemistry, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria.; Landmark University SDG 3 (Good Health and Wellbeing Research Group), Omu-Aran, Kwara State, Nigeria., Evbuomwan IO; Department of Food Science and Microbiology, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria.; Landmark University SDG 3 (Good Health and Wellbeing Research Group), Omu-Aran, Kwara State, Nigeria., Lele KC; Department of Biochemistry, Imo State University, Owerri Imo State, Nigeria., Alejolowo OO; Department of Biochemistry, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria.; Landmark University SDG 3 (Good Health and Wellbeing Research Group), Omu-Aran, Kwara State, Nigeria., Ezea SC; Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka Enugu State, Nigeria., Asogwa NT; Central Research Lab 123B University Road Tanke, Ilorin, Kwara State, Nigeria., Oludipe EO; Department of Food Science and Microbiology, College of Pure and Applied Sciences, Landmark University P.M.B. 1001, Omu Aran, Kwara State, Nigeria.
Jazyk:	angličtina
Zdroj:	Toxicology reports [Toxicol Rep] 2023 Feb 17; Vol. 10, pp. 269-280. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).
DOI:	10.1016/j.toxrep.2023.02.007
Abstrakt:	Some therapeutic and beneficial health properties of the Theobroma cacao leaf have been documented. This study evaluated the ameliorative effect of Theobroma cacao-fortified feed against potassium bromate-induced oxidative damage in male Wistar rats. Thirty rats were randomly grouped into A-E. Except for E (the negative control), the rats in the other groups were administered 0.5 ml of 10 mg/kg body weight of potassium bromate daily using oral gavage and then allowed access to feed and water ad libitum. Groups B, C, and D were fed with 10 %, 20 %, and 30 % leaf-fortified feed respectively, while the negative and positive control (A) was fed with commercial feed. The treatment was carried out consecutively for fourteen days. In the liver and kidney, there was a significant increase (p < 0.05) in total protein concentration, a significant decrease (P < 0.05) in MDA level, and SOD activity in the fortified feed group compared to the positive control. Furthermore, in the serum, there was a significant increase (p < 0.05) in the albumin concentration, and ALT activity, and a significant decrease (p < 0.05) in urea concentration in the fortified feed groups compared to the positive control. The histopathology of the liver and kidney in the treated groups showed moderate cell degeneration compared to the positive control group. Antioxidant activity due to the presence of flavonoids and metal chelating activity of fiber in Theobroma cacao leaf could be responsible for the ameliorative effect of the fortified feed against potassium bromate-induced oxidative damage. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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