Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway.

Autor:	Luo JH; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Li J; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Shen ZC; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Lin XF; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Chen AQ; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Wang YF; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China., Gong ES; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.; Key Laboratory of Environment and Health of Ganzhou, Gannan Medical University, Ganzhou, China., Liu D; Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, China., Zou Q; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.; Key Laboratory of Environment and Health of Ganzhou, Gannan Medical University, Ganzhou, China., Wang XY; School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.; Key Laboratory of Environment and Health of Ganzhou, Gannan Medical University, Ganzhou, China.; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2023 Feb 16; Vol. 10, pp. 1102146. Date of Electronic Publication: 2023 Feb 16 (Print Publication: 2023).
DOI:	10.3389/fnut.2023.1102146
Abstrakt:	Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Luo, Li, Shen, Lin, Chen, Wang, Gong, Liu, Zou and Wang.)
Databáze:	MEDLINE
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