Capturing the multifaceted function of adipose tissue macrophages.

Autor:	Matz AJ; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States., Qu L; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States., Karlinsey K; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States., Vella AT; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.; Institute for Systems Genomics, University of Connecticut, Farmington, CT, United States., Zhou B; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT, United States.; Institute for Systems Genomics, University of Connecticut, Farmington, CT, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Feb 16; Vol. 14, pp. 1148188. Date of Electronic Publication: 2023 Feb 16 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1148188
Abstrakt:	Adipose tissue macrophages (ATMs) bolster obesity-induced metabolic dysfunction and represent a targetable population to lessen obesity-associated health risks. However, ATMs also facilitate adipose tissue function through multiple actions, including adipocyte clearance, lipid scavenging and metabolism, extracellular remodeling, and supporting angiogenesis and adipogenesis. Thus, high-resolution methods are needed to capture macrophages' dynamic and multifaceted functions in adipose tissue. Herein, we review current knowledge on regulatory networks critical to macrophage plasticity and their multifaceted response in the complex adipose tissue microenvironment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Matz, Qu, Karlinsey, Vella and Zhou.)
Databáze:	MEDLINE
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