Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study.

Autor:	Espiritu J; Syntellix AG, Hannover, Germany., Sefa S; Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany., Ćwieka H; Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany., Greving I; Institute of Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, Germany., Flenner S; Institute of Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, Germany., Willumeit-Römer R; Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany., Seitz JM; Syntellix AG, Hannover, Germany., Zeller-Plumhoff B; Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany.
Jazyk:	angličtina
Zdroj:	Bioactive materials [Bioact Mater] 2023 Feb 20; Vol. 26, pp. 14-23. Date of Electronic Publication: 2023 Feb 20 (Print Publication: 2023).
DOI:	10.1016/j.bioactmat.2023.02.018
Abstrakt:	An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and bone. Osteocytes, which are housed and communicate through the lacuno-canalicular network (LCN), are integral to bone health and remodelling processes. Therefore, it is essential to examine the framework of the LCN in response to implant materials or surface treatments. Biodegradable materials offer an alternative solution to permanent implants, which may require revision or removal surgeries. Magnesium alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in vivo . To further tailor their degradation capabilities, surface treatments such as plasma electrolytic oxidation (PEO) have demonstrated to slow degradation. For the first time, the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D imaging. In this pilot study, we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the PEO-coating. Utilising synchrotron-based transmission X-ray microscopy, we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep bone. Bone specimens were explanted after 4, 8, and 12 weeks and regions near the implant surface were prepared for imaging. Findings from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the LCN. However, the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance. Competing Interests: Syntellix AG is a medical technology manufacturer of metallic and bio-absorbable clinical implants. Authors Espiritu and Seitz are employed as Research Associate and Chief Technical Officer, respectively. (© 2023 The Authors.)
Databáze:	MEDLINE
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